INT338102

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.07 Pain Relevance 0

lyase activity (CA4) Golgi apparatus (CA4)

Anatomy Link Frequency blood vessels 1 CA4 (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 1 44.20 COX2 1 41.92 withdrawal 8 5.00 imagery 4 5.00 Pain 2 5.00 palliative 1 5.00 Inflammation 1 5.00 Neuropeptide 1 5.00 Catecholamine 1 5.00

Disease Link Frequency Relevance Heat Cancer 57 96.20 Thyroid Neoplasm 169 94.80 Disease 81 81.52 Malignant Neoplastic Disease 11 58.12 Hypertension 1 19.80 Diarrhoea 3 19.12 Toxicity 2 9.72 Disease Progression 1 8.72 Metastasis 37 5.00 Carcinoma 27 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Unlike the other angiogenesis inhibitors such as bevacizumab, an antibody against VEGF, or the VEGF receptor kinase inhibitors, CA4P is a tubulin-binding vascular disrupting agent that stops blood flow through existing blood vessels, depriving the tumor of its nutrients and oxygen.

CA4P Binding (binding) of in blood vessels associated with cancer

1) Confidence 0.01 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.07 Pain Relevance 0

General Comments

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