INT33811

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Context Info
Confidence 0.39
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.97
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
fat 1
adipose tissues 1
adipocytes 1
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 1 66.76 Quite High
Catecholamine 16 54.16 Quite High
noradrenaline 28 38.80 Quite Low
agonist 9 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 451 99.54 Very High Very High Very High
Hypertension 12 98.72 Very High Very High Very High
Hyperinsulinism 10 97.68 Very High Very High Very High
Syndrome 8 91.68 High High
Insulin Resistance 19 89.24 High High
Polycystic Ovary Syndrome 83 80.44 Quite High
Hypertrophy 1 62.24 Quite High
Diabetes Mellitus 22 46.12 Quite Low
Disorder Of Lipid Metabolism 5 27.48 Quite Low
Coronary Heart Disease 7 19.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, obesity was associated with a decreased perilipin and HSL proteins in both adipose tissues.
Negative_regulation (decreased) of HSL in adipose tissues associated with obesity
1) Confidence 0.39 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.88 Pain Relevance 0.03
Mainly dependent on hormone-sensitive lipase, lipolysis is differently impaired between fat depots in human obesity.
Negative_regulation (impaired) of hormone-sensitive lipase in fat associated with obesity
2) Confidence 0.34 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2804660 Disease Relevance 0.34 Pain Relevance 0
Nevertheless, the reduced absolute number of HSL molecules phosphorylated on Ser659 may at least partly explain the blunted baseline glycerol release in obese compared with lean subjects.
Negative_regulation (reduced) of HSL associated with obesity
3) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.92 Pain Relevance 0
This data suggest that interleukin-2 stimulates lipolysis by decreasing the alpha 2-adrenergic inhibition of hormone-sensitive lipase.
Negative_regulation (inhibition) of hormone-sensitive lipase
4) Confidence 0.20 Published 1986 Journal Surgery Section Abstract Doc Link 3016934 Disease Relevance 0.06 Pain Relevance 0.07
A state of hyperinsulinemia may itself contribute to obesity by the anabolic effect on fat metabolism through adipogenesis with increased uptake of glucose into adipocytes, the production of triglycerides and inhibition of hormone sensitive lipase (Arner 2005).


Negative_regulation (inhibition) of hormone sensitive lipase in adipocytes associated with obesity and hyperinsulinism
5) Confidence 0.11 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.77 Pain Relevance 0

General Comments

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