INT338112

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.94
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Csf1) extracellular space (Csf1) extracellular region (Csf1)
plasma membrane (Csf1)
Anatomy Link Frequency
macrophages 2
F4/80 2
Csf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 3 85.52 High High
ketamine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Buprenorphine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 156 100.00 Very High Very High Very High
Pigmented Villonodular Synovitis 72 99.38 Very High Very High Very High
Myxoid Liposarcoma 3 96.66 Very High Very High Very High
Clear Cell Sarcoma 3 96.18 Very High Very High Very High
Synovial Sarcoma 3 95.78 Very High Very High Very High
Disease 30 95.40 Very High Very High Very High
Giant Cell Tumors 51 94.96 High High
Recurrence 6 92.64 High High
Malignant Neoplastic Disease 3 85.96 High High
Arthritis 3 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor-derived CSF1 overexpression is a common finding in many types of human neoplasms [17, 18].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CSF1 associated with cancer
1) Confidence 0.69 Published 2010 Journal Sarcoma Section Body Doc Link PMC2957133 Disease Relevance 1.52 Pain Relevance 0
The presence of high levels of CSF1 expression, recruiting a large body of macrophages to the tumor site, appears to be a consistent feature in all forms of this disease [3, 4].
Positive_regulation (levels) of Gene_expression (expression) of CSF1 in macrophages associated with cancer and disease
2) Confidence 0.69 Published 2010 Journal Sarcoma Section Body Doc Link PMC2957133 Disease Relevance 1.87 Pain Relevance 0.04
In experiments using other tumor types which do not produce CSF1 (synovial sarcoma, clear cell sarcoma, and myxoid liposarcoma), no host F4/80+ macrophage infiltrates were seen (Cheng and Nielsen, unpublished observations), supporting that their presence in PVNS xenografts indeed occurs as a consequence of tumor CSF1 expression rather than as a reaction to the implantation procedure.
Positive_regulation (consequence) of Gene_expression (expression) of CSF1 in F4/80 associated with pigmented villonodular synovitis, myxoid liposarcoma, cancer, synovial sarcoma and clear cell sarcoma
3) Confidence 0.50 Published 2010 Journal Sarcoma Section Body Doc Link PMC2957133 Disease Relevance 1.55 Pain Relevance 0

General Comments

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