INT338167

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 6.14
Pain Relevance 5.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
signal transducer activity (MC1R) cytoplasm (CDKN2A) pigmentation (MC1R)
Anatomy Link Frequency
hair 1
pigmentation 1
CDKN2A (Homo sapiens)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 1264 100.00 Very High Very High Very High
addiction 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 1232 100.00 Very High Very High Very High
Nevus 248 97.92 Very High Very High Very High
Sunburn 112 90.76 High High
Burns 56 89.72 High High
Disease 40 83.28 Quite High
Skin Cancer 32 81.20 Quite High
Cancer 88 46.64 Quite Low
Death 24 43.36 Quite Low
Retinoblastoma 8 21.68 Low Low
Apoptosis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both hair color and high numbers of nevi were associated with melanoma risk in addition to MC1R variants.ImplicationsIncreased melanoma risk in CDKN2A mutation carriers was associated jointly with host phenotypes and MC1R variants.
CDKN2A Binding (associated) of MC1R in hair associated with melanocortin 1 receptor, melanoma and nevus
1) Confidence 0.42 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 1.33 Pain Relevance 0.57
Although the Italian CDKN2A mutation carriers in our study did not show an association between MC1R and melanoma risk, previous studies of unselected case patients and control subjects from different regions of Italy showed statistically significant associations between MC1R variants and melanoma risk (21,44,45).
CDKN2A Binding (association) of MC1R associated with melanocortin 1 receptor and melanoma
2) Confidence 0.42 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.48 Pain Relevance 1.00
In this study, we analyzed 815 CDKN2A mutation carriers that participated in GenoMEL to assess the association of MC1R variants, alone or in combination with host phenotypes, with melanoma risk in white populations with varying pigmentation characteristics and from countries and continents located at different latitudes with different patterns of sun exposure.
CDKN2A Spec (analyzed) Binding (association) of MC1R in pigmentation associated with melanocortin 1 receptor, sunburn and melanoma
3) Confidence 0.42 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 1.07 Pain Relevance 0.72
Genotyping of CDKN2A and MC1R
CDKN2A Binding (Genotyping) of MC1R associated with melanocortin 1 receptor
4) Confidence 0.40 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.27 Pain Relevance 0.22
Associations between MC1R variants and melanoma affection status (affected vs unaffected) were evaluated in CDKN2A mutation carriers using the generalized estimating equations (GEE) method to take into account familial dependences.
CDKN2A Binding (Associations) of MC1R associated with melanocortin 1 receptor and melanoma
5) Confidence 0.37 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 1.32 Pain Relevance 0.31
The homogeneity of the odds ratios associated with these MC1R variables by type of CDKN2A mutations was tested by the Cochran Q test.
CDKN2A Binding (associated) of MC1R associated with melanocortin 1 receptor
6) Confidence 0.37 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.45 Pain Relevance 1.15
An increase in melanoma risk with increase in the number of MC1R variants was also reported in a recent meta-analysis of the association between MC1R variants and melanoma risk in CDKN2A mutation carriers (50).
CDKN2A Binding (association) of MC1R associated with melanocortin 1 receptor and melanoma
7) Confidence 0.35 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.61 Pain Relevance 0.89
An increase in melanoma risk with increase in the number of MC1R variants was also reported in a recent meta-analysis of the association between MC1R variants and melanoma risk in CDKN2A mutation carriers (50).
CDKN2A Binding (association) of MC1R associated with melanocortin 1 receptor and melanoma
8) Confidence 0.35 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.61 Pain Relevance 0.89

General Comments

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