INT338185

Context Info Confidence 0.19 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 0

cytoplasm (VAV3, AR) nucleoplasm (AR) transport (AR) enzyme binding (AR) DNA binding (AR) cell-cell signaling (AR)

VAV3 (Homo sapiens) AR (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 2 5.00 palliative 1 5.00 fibrosis 1 5.00

Disease Link Frequency Relevance Heat Prostate Cancer 53 82.52 Cancer 49 80.56 Metastasis 18 72.72 Disease 15 23.68 Apoptosis 8 5.00 Hypersensitivity 4 5.00 Hyperplasia 2 5.00 Death 2 5.00 Reproductive System Disorders 2 5.00 Recurrence 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because the effect of VAV3 on cell division and AR activation is dependent on GEF activity, this variant is not oncogenic and has most likely a different function than the full-length protein.

VAV3 Regulation (effect) of Positive_regulation (activation) of AR

1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.49 Pain Relevance 0

General Comments

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