INT3382

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1976
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 33
Total Number 38
Disease Relevance 11.64
Pain Relevance 21.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
nucleus accumbens 4
adrenal medulla 4
neurons 3
ganglia 3
heart 3
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 573 100.00 Very High Very High Very High
Enkephalin 72 100.00 Very High Very High Very High
medulla 33 100.00 Very High Very High Very High
Catecholamine 26 100.00 Very High Very High Very High
Neuropeptide 16 100.00 Very High Very High Very High
Nucleus accumbens 276 99.98 Very High Very High Very High
Raphe 21 99.92 Very High Very High Very High
Clonidine 6 99.78 Very High Very High Very High
Migraine 3 99.68 Very High Very High Very High
Locus ceruleus 14 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 7 99.68 Very High Very High Very High
Aids-related Complex 9 99.48 Very High Very High Very High
Hypoxia 3 99.38 Very High Very High Very High
Stress 47 99.36 Very High Very High Very High
Pheochromocytoma 1 99.34 Very High Very High Very High
Myocardial Infarction 8 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 2 98.68 Very High Very High Very High
Heart Rate Under Development 12 98.36 Very High Very High Very High
Glioma 5 97.48 Very High Very High Very High
Angina 2 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The DBH activity increased about 16% after the exercise stress.
Positive_regulation (increased) of DBH associated with stress
1) Confidence 0.70 Published 1976 Journal Jpn Heart J Section Abstract Doc Link 966380 Disease Relevance 1.12 Pain Relevance 0.28
A tendency to increase DBH activity was shown in the patients with congestive heart failure.
Positive_regulation (increase) of DBH in heart associated with heart rate under development
2) Confidence 0.70 Published 1976 Journal Jpn Heart J Section Abstract Doc Link 966380 Disease Relevance 1.13 Pain Relevance 0.28
In contrast, TH and DBH mRNA levels in the SCG, but not in adrenal medulla, were elevated by ACTH administration, similar to the levels attained after immobilization.
Positive_regulation (elevated) of DBH mRNA in SCG associated with medulla
3) Confidence 0.69 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.58 Pain Relevance 0.31
Fos-DBH positive neurons were also increased by BV acupoint stimulation in the LC and A5.
Positive_regulation (increased) of Fos-DBH in neurons associated with locus ceruleus
4) Confidence 0.67 Published 2004 Journal Mol. Cells Section Abstract Doc Link 15179050 Disease Relevance 0.28 Pain Relevance 0.53
This treatment significantly increased DBH activity in CSF (n = 10,P less than 0.005).
Positive_regulation (increased) of DBH in CSF
5) Confidence 0.66 Published 1980 Journal Brain Res. Section Abstract Doc Link 7363084 Disease Relevance 0 Pain Relevance 0.26
In a previous study we reported 4-5-fold increases in the levels of mRNA encoding tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and neuropeptide tyrosine (NPY) in the rat adrenal medulla immediately after birth.
Positive_regulation (increases) of DBH in adrenal medulla associated with medulla, dopamine and neuropeptide
6) Confidence 0.66 Published 1995 Journal Pediatr. Res. Section Abstract Doc Link 7651752 Disease Relevance 0.07 Pain Relevance 0.43
Thus, the birth-related increases in TH, DBH, NPY, and ENK mRNA levels in the rat adrenal medulla are dependent on postnatal oxygenation.
Positive_regulation (increases) of DBH in adrenal medulla associated with medulla
7) Confidence 0.66 Published 1995 Journal Pediatr. Res. Section Abstract Doc Link 7651752 Disease Relevance 0.08 Pain Relevance 0.40
Increases in DBH are not specific for myocardial infarction but a nonspecific responses to stress.
Positive_regulation (Increases) of DBH associated with stress and myocardial infarction
8) Confidence 0.61 Published 1978 Journal Clin. Chim. Acta Section Abstract Doc Link 729170 Disease Relevance 0.53 Pain Relevance 0.16
There were no consistent changes in plasma DBH, although there was a tendency for DBH to increase from low basal levels and to decrease from high basal levels.
Positive_regulation (increase) of DBH in plasma
9) Confidence 0.57 Published 1980 Journal Brain Res. Section Abstract Doc Link 7363084 Disease Relevance 0 Pain Relevance 0.28
Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test.
Positive_regulation (assayed) of Dopamine-beta-hydroxylase in heart associated with heart rate under development, angina, dopamine, neurocirculatory asthenia, pressure volume 2 under development, coronary artery disease and hypertension
10) Confidence 0.50 Published 1976 Journal Jpn Heart J Section Abstract Doc Link 966380 Disease Relevance 0.75 Pain Relevance 0.23
Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test.
Positive_regulation (responsible) of Dopamine-beta-hydroxylase in blood associated with heart rate under development, angina, dopamine, neurocirculatory asthenia, pressure volume 2 under development, coronary artery disease and hypertension
11) Confidence 0.50 Published 1976 Journal Jpn Heart J Section Abstract Doc Link 966380 Disease Relevance 0.67 Pain Relevance 0.23
Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test.
Positive_regulation (assayed) of DBH in heart associated with heart rate under development, angina, dopamine, neurocirculatory asthenia, pressure volume 2 under development, coronary artery disease and hypertension
12) Confidence 0.50 Published 1976 Journal Jpn Heart J Section Abstract Doc Link 966380 Disease Relevance 0.75 Pain Relevance 0.23
After in vivo ligation for 24-48 h, large amounts of NA and dopamine-beta-hydroxylase (DBH) accumulated in the nerve segment immediately proximal to the ligature (P1).
Positive_regulation (accumulated) of DBH in proximal associated with dopamine and noradrenaline
13) Confidence 0.50 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7418724 Disease Relevance 0 Pain Relevance 0.39
Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test.
Positive_regulation (responsible) of DBH in blood associated with heart rate under development, angina, dopamine, neurocirculatory asthenia, pressure volume 2 under development, coronary artery disease and hypertension
14) Confidence 0.50 Published 1976 Journal Jpn Heart J Section Abstract Doc Link 966380 Disease Relevance 0.67 Pain Relevance 0.23
Here we examined the effect of immobilization stress and treatment with ACTH and glucocorticoids on messenger RNA (mRNA) levels for tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), preproneuropeptide Y (pre-NPY), and proenkephalin in rat superior cervical ganglia (SCG) and in stellate ganglia.
Positive_regulation (levels) of DBH in ganglia associated with stress and dopamine
15) Confidence 0.50 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.47 Pain Relevance 0.29
Here we examined the effect of immobilization stress and treatment with ACTH and glucocorticoids on messenger RNA (mRNA) levels for tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), preproneuropeptide Y (pre-NPY), and proenkephalin in rat superior cervical ganglia (SCG) and in stellate ganglia.
Positive_regulation (levels) of dopamine beta-hydroxylase in ganglia associated with stress and dopamine
16) Confidence 0.50 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.47 Pain Relevance 0.29
L-DOPS is very effective in treatment of deficiency of dopamine-beta-hydroxylase (DBH), the enzyme required for conversion of dopamine to NE in sympathetic nerves.
Positive_regulation (required) of DBH in sympathetic associated with dopamine
17) Confidence 0.49 Published 2006 Journal Cardiovasc Drug Rev Section Abstract Doc Link 17214596 Disease Relevance 0.25 Pain Relevance 0.10
Fos-DBH positive neurons were also increased by BV acupoint stimulation in the LC and A5.
Positive_regulation (increased) of Fos-DBH in neurons associated with locus ceruleus
18) Confidence 0.48 Published 2004 Journal Mol. Cells Section Abstract Doc Link 15179050 Disease Relevance 0.28 Pain Relevance 0.53
The DBH activity was significantly higher in the migraine patients (46.5+/4.5 units) than in the controls (24.9+/2.4 units), whereas no significant difference was observed between the patients with muscle contraction headache (29.4+/4.5 units) and the controls.
Positive_regulation (higher) of DBH in muscle associated with migraine and headache
19) Confidence 0.47 Published 1976 Journal Arch. Neurol. Section Abstract Doc Link 962648 Disease Relevance 0.65 Pain Relevance 0.73
The effect of clonidine on plasma DBH was strongly dependent on the basal enzyme level.
Positive_regulation (dependent) of DBH in plasma associated with clonidine
20) Confidence 0.44 Published 1980 Journal Brain Res. Section Abstract Doc Link 7363084 Disease Relevance 0 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox