INT338234

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VAV3) plasma membrane (VAV3) cytoplasm (VAV3)
VAV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 106 75.80 Quite High
Cancer 98 73.36 Quite High
Metastasis 36 51.68 Quite High
Apoptosis 16 10.88 Low Low
Disease 30 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Reproductive System Disorders 4 5.00 Very Low Very Low Very Low
Recurrence 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Validated primers and probes from TaqMan Gene Expression Assays (Applied Biosystems) were used for quantification of VAV3 (Hs00916821_m1), TWIST1 (Hs00361186_m1), DKK3 (Hs00951307_m1) and GAPDH (Hs99999905_m1), according to the PCR settings provided by Applied Biosystems.
Localization (quantification) of VAV3
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.06 Pain Relevance 0
Src kinases are also activators of VAV3 and TWIST1, either directly by phosphorylating and releasing inhibitory tyrosine Y173 of VAV3, or indirectly by activating STAT3, a transcription activator for TWIST1 [58], [59].
Localization (releasing) of VAV3
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.32 Pain Relevance 0

General Comments

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