INT338234

Context Info Confidence 0.61 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.38 Pain Relevance 0

cytosol (VAV3) plasma membrane (VAV3) cytoplasm (VAV3)

VAV3 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 4 5.00 palliative 2 5.00 fibrosis 2 5.00

Disease Link Frequency Relevance Heat Prostate Cancer 106 75.80 Cancer 98 73.36 Metastasis 36 51.68 Apoptosis 16 10.88 Disease 30 5.00 Hypersensitivity 8 5.00 Hyperplasia 4 5.00 Death 4 5.00 Reproductive System Disorders 4 5.00 Recurrence 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Validated primers and probes from TaqMan Gene Expression Assays (Applied Biosystems) were used for quantification of VAV3 (Hs00916821_m1), TWIST1 (Hs00361186_m1), DKK3 (Hs00951307_m1) and GAPDH (Hs99999905_m1), according to the PCR settings provided by Applied Biosystems.

Localization (quantification) of VAV3

1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.06 Pain Relevance 0

Src kinases are also activators of VAV3 and TWIST1, either directly by phosphorylating and releasing inhibitory tyrosine Y173 of VAV3, or indirectly by activating STAT3, a transcription activator for TWIST1 [58], [59].

Localization (releasing) of VAV3

2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.32 Pain Relevance 0

General Comments

This test has worked.