INT338236

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 8.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VAV3) plasma membrane (VAV3) cytoplasm (VAV3)
Anatomy Link Frequency
LNCAP 2
VAV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 18 5.00 Very Low Very Low Very Low
palliative 9 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 477 99.84 Very High Very High Very High
Metastasis 162 99.52 Very High Very High Very High
Disease 135 99.52 Very High Very High Very High
Cancer 441 98.92 Very High Very High Very High
Adenocarcinoma 9 79.56 Quite High
Apoptosis 72 33.92 Quite Low
Reproductive System Disorders 18 27.12 Quite Low
Carcinoma 9 14.04 Low Low
Hypersensitivity 36 5.00 Very Low Very Low Very Low
Hyperplasia 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the decrease of VAV3 expression in PCa progression was unexpected, considering the function of VAV3 as a potential oncogene.
Gene_expression (expression) of VAV3 associated with prostate cancer
1) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.62 Pain Relevance 0
Surprisingly, in our patient derived samples, VAV3 expression decreased gradually during PCa progression, with the lowest levels in metastatic and hormone-refractory samples (Fig. 5C).
Gene_expression (expression) of VAV3 associated with prostate cancer
2) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.92 Pain Relevance 0
Previous studies have implicated VAV3 in the pathogenesis of the prostate: (i) VAV3 expression has been detected in the prostate, at increased levels in cancer cells [67]; (ii) it has been shown to interact with the AR pathway, stimulating ligand-independent cell growth in LNCAP-hormone-refractory cells [67], [68], and (iii) targeting of constitutively active VAV3 expression to the prostate induced PCa in mice [69].
Gene_expression (expression) of VAV3 in LNCAP associated with cancer and prostate cancer
3) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.96 Pain Relevance 0
Previous studies have implicated VAV3 in the pathogenesis of the prostate: (i) VAV3 expression has been detected in the prostate, at increased levels in cancer cells [67]; (ii) it has been shown to interact with the AR pathway, stimulating ligand-independent cell growth in LNCAP-hormone-refractory cells [67], [68], and (iii) targeting of constitutively active VAV3 expression to the prostate induced PCa in mice [69].
Gene_expression (expression) of VAV3 in LNCAP associated with cancer and prostate cancer
4) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.14 Pain Relevance 0
Furthermore, Kaplan-Meier analysis showed a direct correlation between VAV3 expression levels and metastasis-free survival (Fig. 5D).
Gene_expression (expression) of VAV3 associated with metastasis
5) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.73 Pain Relevance 0
VAV3 expression decreased gradually during PCa progression, with the lowest levels observed in metastatic prostate tumors (P-value ?
Gene_expression (expression) of VAV3 associated with prostate cancer
6) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.38 Pain Relevance 0
Based on their recognized pathological functions and consistent deregulation in multiple PCa databases, twist homolog 1 (TWIST1), vav 3 guanine nucleotide exchange factor (VAV3) and dickkopf homolog 3 (DKK3) were selected for their potential role in the bypass of the AR pathway.
Gene_expression (selected) of vav 3 guanine nucleotide exchange factor associated with prostate cancer
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.13 Pain Relevance 0
Based on their recognized pathological functions and consistent deregulation in multiple PCa databases, twist homolog 1 (TWIST1), vav 3 guanine nucleotide exchange factor (VAV3) and dickkopf homolog 3 (DKK3) were selected for their potential role in the bypass of the AR pathway.
Gene_expression (selected) of VAV3 associated with prostate cancer
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.11 Pain Relevance 0
Both VAV3 and TWIST1 are overexpressed in PC346DCC cells, and survey of 7 previous microarray studies revealed a consistent up-regulation in metastatic patient material (Fig. 4C).
Gene_expression (overexpressed) of VAV3
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.47 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox