INT338243

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VAV3) plasma membrane (VAV3) cytoplasm (VAV3)
VAV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 106 99.96 Very High Very High Very High
Disease 30 99.52 Very High Very High Very High
Metastasis 36 94.00 High High
Cancer 98 90.44 High High
Adenocarcinoma 2 79.56 Quite High
Apoptosis 16 33.92 Quite Low
Carcinoma 2 11.60 Low Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VAV3 expression decreased gradually during PCa progression, with the lowest levels observed in metastatic prostate tumors (P-value ?
Positive_regulation (during) of Gene_expression (expression) of VAV3 associated with prostate cancer
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.44 Pain Relevance 0
Both VAV3 and TWIST1 are overexpressed in PC346DCC cells, and survey of 7 previous microarray studies revealed a consistent up-regulation in metastatic patient material (Fig. 4C).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of VAV3
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.47 Pain Relevance 0

General Comments

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