INT338248

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VAV3) plasma membrane (VAV3) cytoplasm (VAV3)
VAV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 159 99.84 Very High Very High Very High
Disease 45 99.52 Very High Very High Very High
Cancer 147 99.40 Very High Very High Very High
Metastasis 54 94.00 High High
Adenocarcinoma 3 79.56 Quite High
Apoptosis 24 5.00 Very Low Very Low Very Low
Hypersensitivity 12 5.00 Very Low Very Low Very Low
Hyperplasia 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Reproductive System Disorders 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the decrease of VAV3 expression in PCa progression was unexpected, considering the function of VAV3 as a potential oncogene.
Negative_regulation (decrease) of Gene_expression (expression) of VAV3 associated with prostate cancer
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.62 Pain Relevance 0
Surprisingly, in our patient derived samples, VAV3 expression decreased gradually during PCa progression, with the lowest levels in metastatic and hormone-refractory samples (Fig. 5C).
Negative_regulation (decreased) of Gene_expression (expression) of VAV3 associated with prostate cancer
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.92 Pain Relevance 0
VAV3 expression decreased gradually during PCa progression, with the lowest levels observed in metastatic prostate tumors (P-value ?
Negative_regulation (decreased) of Gene_expression (expression) of VAV3 associated with prostate cancer
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.38 Pain Relevance 0

General Comments

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