INT338411

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.58
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17f) extracellular region (Il17f)
Anatomy Link Frequency
Th17 cells 4
goblet cell 2
Il17f (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 127 99.56 Very High Very High Very High
Multiple sclerosis 161 97.24 Very High Very High Very High
cytokine 193 91.80 High High
chemokine 23 83.32 Quite High
Inflammatory mediators 3 81.92 Quite High
Spinal cord 2 78.00 Quite High
Crohn's disease 48 76.76 Quite High
Arthritis 3 60.52 Quite High
Central nervous system 27 21.80 Low Low
tolerance 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 136 99.56 Very High Very High Very High
Asthma 312 98.80 Very High Very High Very High
Demyelinating Disease 178 97.24 Very High Very High Very High
Inflammatory Bowel Disease 55 97.20 Very High Very High Very High
Autoimmune Disease 55 96.92 Very High Very High Very High
Eosinophilia 24 94.60 High High
Hyperplasia 12 93.20 High High
Disease 163 93.04 High High
Adhesions 8 92.40 High High
Multiple Sclerosis 23 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although increased expression of IL17A, IL17F, IL21 and IL26 was detected in inflamed ileal samples, expression of the indispensable Th17 cell differentiation factors TGFB1 and IL23A, the signaling molecule STAT3 and the Th17 recruitment factors CCR6 and CCL20 were unchanged.


Positive_regulation (increased) of Gene_expression (expression) of IL17F in Th17 cell
1) Confidence 0.29 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.90 Pain Relevance 0.33
Increased expression of IL-17F has already been detected in asthmatic patients after allergen challenge.
Positive_regulation (Increased) of Gene_expression (expression) of IL-17F associated with asthma
2) Confidence 0.10 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.59 Pain Relevance 0.16
Pulmonary overexpression of IL-17F in mice resulted not only in airway neutrophilia but also in an amplified allergen-induced immune-response including increased airway eosinophilia, AHR, and goblet cell hyperplasia [83].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-17F in goblet cell associated with hyperplasia and eosinophilia
3) Confidence 0.07 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.64 Pain Relevance 0.20
In vitro restimulation of these cells resulted in production of IL-17A and IL-17F, IL-22, IL-26, lymphotoxin ?
Positive_regulation (resulted) of Gene_expression (production) of IL-17F
4) Confidence 0.07 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.96 Pain Relevance 0.10
Th17 cells produce IL-17A and IL-17F, which are upregulated in chronic lesions [172, 173], and IL-22 which is also involved in MS pathogenesis.
Positive_regulation (upregulated) of Gene_expression (produce) of IL-17F in Th17 cells associated with multiple sclerosis
5) Confidence 0.04 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.48 Pain Relevance 0.42

General Comments

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