INT338494

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Context Info
Confidence 0.79
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.84
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (RNLS) extracellular region (RNLS)
Anatomy Link Frequency
heart 1
kidney 1
RNLS (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 45 99.54 Very High Very High Very High
Parenteral administration 3 93.12 High High
ischemia 54 83.60 Quite High
monoamine 3 33.20 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 3 98.00 Very High Very High Very High
Coronary Heart Disease 48 97.92 Very High Very High Very High
Left Ventricular Hypertrophy 18 94.80 High High
Renal Disease 12 87.64 High High
Coronary Artery Disease 36 84.24 Quite High
Stroke 6 81.68 Quite High
Myocardial Infarction 18 78.88 Quite High
Bradycardia 3 76.88 Quite High
Death 3 63.60 Quite High
Hypertension 15 52.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies in animal models are warranted to investigate the relative contributions of renalase secreted from the kidney and the heart to the inhibition of cardiac hypertrophy.
Localization (secreted) of renalase in heart associated with coronary heart disease
1) Confidence 0.79 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.92 Pain Relevance 0.11
We recently identified renalase, a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood by the kidney, metabolizes circulating catecholamines, and is deficient in chronic kidney disease [7].
Localization (secreted) of renalase in kidney associated with chronic renal failure and catecholamine
2) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.44 Pain Relevance 0.17
Excess catecholamines promote the activity, secretion, and synthesis of renalase, providing a novel pathway of negative-feedback homeostatic control [8].
Localization (secretion) of renalase associated with catecholamine
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.47 Pain Relevance 0.19

General Comments

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