INT338496

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.89
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (RNLS) extracellular region (RNLS)
Anatomy Link Frequency
coronary artery 1
RNLS (Homo sapiens)
RNLS - E37D (3)
Pain Link Frequency Relevance Heat
Catecholamine 75 98.76 Very High Very High Very High
ischemia 90 96.92 Very High Very High Very High
imagery 10 96.00 Very High Very High Very High
monoamine 5 82.56 Quite High
Parenteral administration 5 53.24 Quite High
tolerance 5 32.12 Quite Low
Angina 5 15.40 Low Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 80 98.44 Very High Very High Very High
Cv Unclassified Under Development 80 96.92 Very High Very High Very High
Coronary Artery Disease 60 94.40 High High
Obesity 20 87.08 High High
Hypertension 25 85.68 High High
Stress 25 76.64 Quite High
Left Ventricular Hypertrophy 30 70.68 Quite High
Myocardial Infarction 30 60.08 Quite High
Metastasis 20 56.08 Quite High
Chronic Renal Failure 5 45.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To explore the possibility of effect modification by age, we tested for statistical interactions between renalase genotype and measures of cardiovascular structure and function in the multivariable adjusted models.
renalase Binding (interactions) of
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.09 Pain Relevance 0
In conclusion, we found an association of the renalase Glu37Asp polymorphism (C allele) with cardiac hypertrophy, dysfunction, and ischemia in a cross-sectional study of individuals with stable coronary artery disease and normal renal function.
renalase (E37D) Binding (association) of in coronary artery associated with coronary artery disease, ischemia and coronary heart disease
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.44 Pain Relevance 0.14
In the presence of oxygen the reduced renalase-FADH complex metabolizes subtrates such as catecholamines.
renalase-FADH Binding (complex) of associated with catecholamine
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.40 Pain Relevance 0.12
A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described.
renalase (E37D) Binding (binding) of
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.41 Pain Relevance 0.13
A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described.
renalase (E37D) Binding (binding) of
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2958117 Disease Relevance 0.55 Pain Relevance 0.16

General Comments

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