INT338501

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 3.74
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (RNLS) extracellular region (RNLS)
Anatomy Link Frequency
plasma 1
liver 1
skeletal muscle 1
heart 1
molar 1
RNLS (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 135 99.24 Very High Very High Very High
Parenteral administration 9 93.12 High High
monoamine 9 91.12 High High
ischemia 162 83.60 Quite High
imagery 18 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
Angina 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 9 97.40 Very High Very High Very High
Coronary Heart Disease 144 97.28 Very High Very High Very High
Cardiovascular Disease 9 94.12 High High
Renal Disease 36 89.84 High High
Left Ventricular Hypertrophy 54 87.80 High High
Death 9 84.52 Quite High
Coronary Artery Disease 108 84.24 Quite High
Myocardial Infarction 54 78.88 Quite High
Cv Unclassified Under Development 144 77.36 Quite High
Hypertension 45 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, renalase protein expression in cardiac tissue from nephrectomized rats was significantly lower than in controls.
Gene_expression (in express) of renalase protein
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.94 Pain Relevance 0.08
It is the predominant human renalase protein detectable in plasma, kidney, heart, skeletal muscle, and liver.
Gene_expression (detectable) of renalase protein in heart
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.39 Pain Relevance 0.19
Brief surges in catecholamine levels increase the activity, secretion, and synthesis of renalase resulting in accelerated degradation of catecholamines via a negative feedback mechanism.
Gene_expression (synthesis) of renalase associated with catecholamine
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.38 Pain Relevance 0.21
The amount of WST-1 reduced by renalase was calculated from the increase in absorbance at 450 nm, and using a molar extinction coefficient of 37,000 M?
Gene_expression (reduced) of renalase in molar
4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0 Pain Relevance 0
Excess catecholamines promote the activity, secretion, and synthesis of renalase, providing a novel pathway of negative-feedback homeostatic control [8].
Gene_expression (synthesis) of renalase associated with catecholamine
5) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.47 Pain Relevance 0.19
It is the predominant human renalase protein detectable in plasma, kidney, heart, skeletal muscle, and liver.
Gene_expression (detectable) of renalase protein in kidney
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.39 Pain Relevance 0.19
It is the predominant human renalase protein detectable in plasma, kidney, heart, skeletal muscle, and liver.
Gene_expression (detectable) of renalase protein in skeletal muscle
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.39 Pain Relevance 0.19
It is the predominant human renalase protein detectable in plasma, kidney, heart, skeletal muscle, and liver.
Gene_expression (detectable) of renalase protein in plasma
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.39 Pain Relevance 0.19
It is the predominant human renalase protein detectable in plasma, kidney, heart, skeletal muscle, and liver.
Gene_expression (detectable) of renalase protein in liver
9) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.39 Pain Relevance 0.19

General Comments

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