INT33857

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.98
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NTS) extracellular region (NTS)
Anatomy Link Frequency
basal ganglia 1
NTS (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 3 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
mu opioid receptor 1 100.00 Very High Very High Very High
opiate 4 99.80 Very High Very High Very High
Pain 10 99.04 Very High Very High Very High
Dopamine 4 96.84 Very High Very High Very High
Serotonin 2 95.56 Very High Very High Very High
pain pelvic 1 93.92 High High
Disease Link Frequency Relevance Heat
Infection 11 99.96 Very High Very High Very High
Disease 23 99.72 Very High Very High Very High
Bacteremia 1 99.12 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 186 98.92 Very High Very High Very High
Hepatitis 42 98.32 Very High Very High Very High
Necrosis 6 95.52 Very High Very High Very High
Cervical Cancer 2 95.44 Very High Very High Very High
Reprotox - General 3 1 93.92 High High
Low Back Pain 2 92.88 High High
Plantar Fasciitis 1 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurotensin, substance P, delta and mu opioid receptors are decreased in basal ganglia of Parkinson's disease patients.
Negative_regulation (decreased) of Neurotensin in basal ganglia associated with analgesic, mu opioid receptor, disease and substance p
1) Confidence 0.42 Published 1994 Journal Neuroscience Section Title Doc Link 7969897 Disease Relevance 0.41 Pain Relevance 0.74
In nigral specimens taken from patients with idiopathic Parkinson's disease, substantial reductions in somatostatin, neurotensin, mu-opiate and kappa-opiate receptors contrast with more modest reductions in dopamine and benzodiazepine I receptor subtypes.
Negative_regulation (reductions) of neurotensin associated with dopamine, somatostatin, opiate and disease
2) Confidence 0.36 Published 1986 Journal Ann. Neurol. Section Abstract Doc Link 3019228 Disease Relevance 0.17 Pain Relevance 0.70
Although food-borne diseases caused by NTS are representative of NTS infections in human, bacteremia and other invasive diseases are also caused by NTS.
Negative_regulation (representative) of NTS associated with bacteremia, disease and infection
3) Confidence 0.35 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693839 Disease Relevance 0.70 Pain Relevance 0
In humans, prospective, placebo-controlled, double-blind studies have also provided evidence for effectiveness of BoNT therapy in a number of painful disorders.
Negative_regulation (effectiveness) of BoNT associated with pain
4) Confidence 0.35 Published 2008 Journal Nature clinical practice. Neurology Section Abstract Doc Link 19043424 Disease Relevance 1.52 Pain Relevance 1.50
Failure attributable to biopsy (false negative) was suspected when the biopsy was smaller than 15 mm and fragmented, in the absence of risk factors of NT failure and with at least another sign of steato-hepatitis not belonging to Kleiner scoring system, such as piece meal necrosis.
Negative_regulation (failure) of NT associated with necrosis and hepatitis
5) Confidence 0.05 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 0.97 Pain Relevance 0.04
Diagnostic values of NT for predicting borderline NASH and NASH in different groups, are given in Table 4 for the concordance with biopsy results, and in Table 5 for sensitivity, specificity and predictive values.
Negative_regulation (values) of NT associated with nash(non-alcoholic steatohepatitis)
6) Confidence 0.05 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.22 Pain Relevance 0.08

General Comments

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