INT33861

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.60
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
plasma 2
mammary gland 2
brain 2
uterine 2
ovary 2
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 38 99.32 Very High Very High Very High
Dismenorea 6 94.96 High High
Potency 7 93.32 High High
Opioid 3 88.24 High High
Neuropeptide 8 80.12 Quite High
agonist 1 67.60 Quite High
anesthesia 2 25.00 Low Low
amygdala 10 10.16 Low Low
ketamine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 6 94.96 High High
Hyperphagia 3 90.72 High High
Appetite Loss 1 79.04 Quite High
Fatigue 1 53.00 Quite High
Body Weight 1 49.52 Quite Low
Urological Neuroanatomy 7 5.00 Very Low Very Low Very Low
Aids-related Complex 3 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in mid-pregnancy the excitability of these neurons is reduced, central dendritic oxytocin release is inhibited and patterns of oxytocin receptor binding in the brain alter.
Negative_regulation (inhibited) of oxytocin Binding (binding) of in brain
1) Confidence 0.42 Published 2007 Journal Physiol. Behav. Section Abstract Doc Link 17512024 Disease Relevance 0.34 Pain Relevance 0.29
In conclusion, TT-235 may inhibit the uterine response to oxytocin by decreasing oxytocin receptor numbers and oxytocin binding affinity, which might explain the prolonged oxytocin antagonist activity of TT-235.
Negative_regulation (decreasing) of oxytocin Spec (might) Binding (affinity) of in uterine associated with antagonist
2) Confidence 0.35 Published 2004 Journal In Vivo Section Abstract Doc Link 15646817 Disease Relevance 0 Pain Relevance 0.12
To determine the site of metal ion action, we measured the effects of Mn2+, another potentiating metal ion, on the ability of a series of peptides to inhibit the binding of [3H]OT to receptor sites on both uterine myometrial and mammary gland plasma membranes.
Negative_regulation (inhibit) of OT Binding (binding) of in mammary gland
3) Confidence 0.29 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019637 Disease Relevance 0.09 Pain Relevance 0.18
We found a generally good correlation between the ability of the analogs to inhibit [3H]OT binding to both receptor systems and their biological potencies.
Negative_regulation (inhibit) of OT Binding (binding) of
4) Confidence 0.29 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019637 Disease Relevance 0.07 Pain Relevance 0.18
When incubated with purified plasma membranes from rat or human myometrial tissue, OPC-21268 inhibited the specific receptor binding of tritiated oxytocin and vasopressin in a dose-dependent and reversible way.
Negative_regulation (inhibited) of oxytocin Binding (binding) of in plasma
5) Confidence 0.26 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566118 Disease Relevance 0.09 Pain Relevance 0.14
Previous studies of the effects on neonatal manipulation of OT have used a single dose of OT (3 ?
Negative_regulation (used) of OT Binding (dose) of
6) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2048512 Disease Relevance 0 Pain Relevance 0.03
Compound 1 competitively inhibits binding of [3H]oxytocin and the peptide antagonist 125I-ornithine vasotocin analog to human and rat oxytocin receptor expressed in human embryonic kidney 293-EBNA or Chinese hamster ovary cells with nanomolar potency.
Negative_regulation (inhibits) of oxytocin Binding (binding) of in ovary associated with antagonist and potency
7) Confidence 0.02 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12660315 Disease Relevance 0 Pain Relevance 0.21

General Comments

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