INT338681

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.22
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Aff3) nucleus (Aff3)
Anatomy Link Frequency
blood 2
esophagus 1
Aff3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 282 99.66 Very High Very High Very High
agonist 12 85.36 High High
Calcitonin gene-related peptide 24 71.36 Quite High
antagonist 30 50.00 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
tissue acidosis 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 156 100.00 Very High Very High Very High
Injury 132 91.80 High High
Acid Reflux 30 66.00 Quite High
Peripheral Arterial Disease 6 45.92 Quite Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Acidosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that luminal acid stimulates CSAN, and that Laf enhances the hyperemic response to acid via CSAN activation or modulation, with a resultant increase of pHint.Fig. 4Effect of Laf with acid on pHint and blood flow in rat esophagus.
Positive_regulation (increase) of Laf in esophagus
1) Confidence 0.56 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.24 Pain Relevance 0.56
The effects of Laf were abolished by prior de-afferentation as a result of high-dose capsaicin pretreatment (Cap-t) (Fig. 3a, b), suggesting that Laf-induced hyperemia is mediated by the activation of CSAN.Fig. 1Effect of luminal capsaicin (Cap) on interstitial pH (pHint) and blood flow in rat esophagus. pHint (a) and blood flow (b) were monitored during the luminal perfusion of Cap (30 and 100 ?
Positive_regulation (mediated) of Laf-induced in blood associated with qutenza and increased venous pressure under development
2) Confidence 0.41 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.19 Pain Relevance 1.02
The effects of Laf were abolished by prior de-afferentation as a result of high-dose capsaicin pretreatment (Cap-t) (Fig. 3a, b), suggesting that Laf-induced hyperemia is mediated by the activation of CSAN.Fig. 1Effect of luminal capsaicin (Cap) on interstitial pH (pHint) and blood flow in rat esophagus. pHint (a) and blood flow (b) were monitored during the luminal perfusion of Cap (30 and 100 ?
Positive_regulation (effects) of Laf in blood associated with qutenza and increased venous pressure under development
3) Confidence 0.41 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.19 Pain Relevance 1.05
Cap-t abolished the Laf-induced pHint increase during the basal and acid challenge periods, and further acidified pHint during the acid challenge period (Fig. 4a).
Positive_regulation (increase) of Laf-induced associated with qutenza
4) Confidence 0.38 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.20 Pain Relevance 0.44
We perfused Laf during the basal and also during the challenge periods in order to maximize its effects on mucosal defenses.
Positive_regulation (perfused) of Laf
5) Confidence 0.35 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.09 Pain Relevance 0.49
Laf was provided by Taiho Pharmaceutical Inc (Tokyo, Japan).
Positive_regulation (provided) of Laf
6) Confidence 0.33 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.32 Pain Relevance 0.35

General Comments

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