INT338690

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) nucleolus (Aff3) plasma membrane (Trpv1)
nucleus (Aff3) lipid metabolic process (Trpv1)
Aff3 (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 4 98.90 Very High Very High Very High
qutenza 47 98.64 Very High Very High Very High
agonist 2 78.16 Quite High
Pain 1 59.20 Quite High
antagonist 5 50.00 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
tissue acidosis 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 26 83.04 Quite High
Injury 22 73.00 Quite High
Acid Reflux 5 61.60 Quite High
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Acidosis 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies have failed to document a direct interaction between Laf and TRPV1 [12, 14], whereas Laf potentiates Cap-induced CGRP release from the gastric mucosa [14], suggesting that Laf sensitizes TRPV1 or interacts at alternate components of the capsaicin pathway.
Laf Positive_regulation (sensitizes) of TRPV1 associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.39 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.40 Pain Relevance 0.67

General Comments

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