INT338691

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.21
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) nucleolus (Aff3) nucleus (Aff3)
plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Trpv1 (Rattus norvegicus)
Aff3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 141 100.00 Very High Very High Very High
Calcitonin gene-related peptide 12 98.90 Very High Very High Very High
agonist 6 83.72 Quite High
Pain 3 64.76 Quite High
antagonist 15 50.00 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
tissue acidosis 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acid Reflux 15 96.80 Very High Very High Very High
Increased Venous Pressure Under Development 78 95.44 Very High Very High Very High
Injury 66 95.40 Very High Very High Very High
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Acidosis 3 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since Laf ingestion, perhaps due to its indirect interaction with TRPV1, does not provoke a burning sensation, it might prove useful in the therapy of heartburn, acid-induced esophageal injury, and related disorders.
TRPV1 Binding (interaction) of Laf associated with acid reflux and injury
1) Confidence 0.24 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.46 Pain Relevance 0.51
In vitro studies have failed to document a direct interaction between Laf and TRPV1 [12, 14], whereas Laf potentiates Cap-induced CGRP release from the gastric mucosa [14], suggesting that Laf sensitizes TRPV1 or interacts at alternate components of the capsaicin pathway.
capsaicin Binding (interacts) of Laf associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.24 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.41 Pain Relevance 0.67
In vitro studies have failed to document a direct interaction between Laf and TRPV1 [12, 14], whereas Laf potentiates Cap-induced CGRP release from the gastric mucosa [14], suggesting that Laf sensitizes TRPV1 or interacts at alternate components of the capsaicin pathway.
TRPV1 Binding (interaction) of Laf associated with qutenza and calcitonin gene-related peptide
3) Confidence 0.24 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2958262 Disease Relevance 0.34 Pain Relevance 0.70

General Comments

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