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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.83
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg)
Anatomy Link Frequency
midbrain 1
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 3 99.84 Very High Very High Very High
Opioid 5 99.20 Very High Very High Very High
midbrain 6 99.12 Very High Very High Very High
agonist 6 98.74 Very High Very High Very High
nMDA receptor antagonist 1 96.48 Very High Very High Very High
Dopamine 35 86.16 High High
Glutamate 3 85.08 High High
Potency 1 84.44 Quite High
Neuropeptide 1 74.68 Quite High
Enkephalin 1 73.20 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 220 92.80 High High
Drug Induced Neurotoxicity 1 86.56 High High
Toxicity 4 85.44 High High
Congenital Anomalies 44 51.72 Quite High
Disease 26 50.24 Quite High
Holoprosencephaly 5 48.16 Quite Low
Epilepsy 3 40.24 Quite Low
Brain Disease 2 34.28 Quite Low
Infantile Spasms 1 15.56 Low Low
Stress 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The assay conditions described should extend the use of agonist-stimulated [35S]GTPgammaS autoradiography to receptors, which produce low levels of [35S]GTPgammaS binding and to the measurement of changes in receptor-G protein coupling.
Gene_expression (produce) of GTPgammaS associated with agonist
1) Confidence 0.59 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11430907 Disease Relevance 0 Pain Relevance 0.34
Both Gpp(NH)p and GTP gamma S produce a concentration-dependent increase in the Km(app) of GTPase, without affecting its Vmax, indicating a competitive inhibition.
Neg (without) Gene_expression (produce) of GTP gamma S
2) Confidence 0.03 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3020173 Disease Relevance 0 Pain Relevance 0.43
Galanin receptor 2 null mutant mice also exhibit an anxiogenic-like phenotype,222,223 which parallels the effects of BPA, DBP, DCHP, and DEHP injection in the midbrain of rats at 5 days of age that reduces gene expression of galanin receptor 2.172


Gene_expression (expression) of GTP-gamma-S in midbrain associated with midbrain
3) Confidence 0.01 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.83 Pain Relevance 0.30

General Comments

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