INT33884

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1986
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.83
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg)
Anatomy Link Frequency
midbrain 1
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 3 99.84 Very High Very High Very High
Opioid 5 99.20 Very High Very High Very High
midbrain 6 99.12 Very High Very High Very High
agonist 6 98.74 Very High Very High Very High
nMDA receptor antagonist 1 96.48 Very High Very High Very High
Dopamine 35 86.16 High High
Glutamate 3 85.08 High High
Potency 1 84.44 Quite High
Neuropeptide 1 74.68 Quite High
Enkephalin 1 73.20 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 220 92.80 High High
Drug Induced Neurotoxicity 1 86.56 High High
Toxicity 4 85.44 High High
Congenital Anomalies 44 51.72 Quite High
Disease 26 50.24 Quite High
Holoprosencephaly 5 48.16 Quite Low
Epilepsy 3 40.24 Quite Low
Brain Disease 2 34.28 Quite Low
Infantile Spasms 1 15.56 Low Low
Stress 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The assay conditions described should extend the use of agonist-stimulated [35S]GTPgammaS autoradiography to receptors, which produce low levels of [35S]GTPgammaS binding and to the measurement of changes in receptor-G protein coupling.
Gene_expression (produce) of GTPgammaS associated with agonist
1) Confidence 0.59 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11430907 Disease Relevance 0 Pain Relevance 0.34
Both Gpp(NH)p and GTP gamma S produce a concentration-dependent increase in the Km(app) of GTPase, without affecting its Vmax, indicating a competitive inhibition.
Neg (without) Gene_expression (produce) of GTP gamma S
2) Confidence 0.03 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3020173 Disease Relevance 0 Pain Relevance 0.43
Galanin receptor 2 null mutant mice also exhibit an anxiogenic-like phenotype,222,223 which parallels the effects of BPA, DBP, DCHP, and DEHP injection in the midbrain of rats at 5 days of age that reduces gene expression of galanin receptor 2.172

[(35)S]GTP-gamma-S.

Gene_expression (expression) of GTP-gamma-S in midbrain associated with midbrain
3) Confidence 0.01 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.83 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox