INT338859

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.45
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (DGKH) plasma membrane (DGKH) nucleus (DGKH)
cytoplasm (DGKH)
DGKH (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 48 81.00 Quite High
nMDA receptor 3 58.92 Quite High
Calcium channel 6 44.72 Quite Low
Neurotransmitter 6 41.36 Quite Low
Serotonin 9 8.20 Low Low
Lamotrigine 69 5.00 Very Low Very Low Very Low
depression 33 5.00 Very Low Very Low Very Low
carbamazepine 27 5.00 Very Low Very Low Very Low
anticonvulsant 24 5.00 Very Low Very Low Very Low
gABA 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 375 99.76 Very High Very High Very High
Affective Disorder 6 84.72 Quite High
Disease 21 81.00 Quite High
Post-traumatic Stress Disorder 3 44.24 Quite Low
Depression 42 5.00 Very Low Very Low Very Low
Recurrence 24 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Psychosis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the genes possibly contributing to BD susceptibiliy the diacylglycerol kinase eta (DGKH), encoding for an enzyme that phosphorylates the second messenger diacylglycerol, was first found to be associated with BD in the GWAS by Baum et al. [12], although replication was not uniformly displayed by subsequent studies [22–24].
DGKH Binding (associated) of associated with manic depressive disorder
1) Confidence 0.35 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.87 Pain Relevance 0
As we mentioned earlier, several authors showed that the DGKH gene was associated with BD.
DGKH gene Binding (associated) of associated with manic depressive disorder
2) Confidence 0.08 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.71 Pain Relevance 0.10
Among the genes possibly contributing to BD susceptibiliy the diacylglycerol kinase eta (DGKH), encoding for an enzyme that phosphorylates the second messenger diacylglycerol, was first found to be associated with BD in the GWAS by Baum et al. [12], although replication was not uniformly displayed by subsequent studies [22–24].
diacylglycerol kinase eta Binding (associated) of associated with manic depressive disorder
3) Confidence 0.06 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.87 Pain Relevance 0

General Comments

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