INT338875

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tph2) cellular_component (Tph2) response to stress (Tph2)
Tph2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe 1 95.36 Very High Very High Very High
Serotonin 3 93.16 High High
depression 11 89.80 High High
antidepressant 1 88.92 High High
carbamazepine 9 74.16 Quite High
bDMF 16 46.76 Quite Low
Neurotransmitter 2 39.88 Quite Low
Lamotrigine 23 5.00 Very Low Very Low Very Low
anticonvulsant 8 5.00 Very Low Very Low Very Low
gABA 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 14 89.80 High High
Shock 1 75.56 Quite High
Neurodegenerative Disease 4 69.00 Quite High
Apoptosis 4 29.20 Quite Low
Manic Depressive Disorder 125 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 6 5.00 Very Low Very Low Very Low
Psychosis 4 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the same study, the authors reported that short-term lithium treatment (8 days) resulted in a 45% decrease in tryptophan hydroxylase 2 (TPH2) expression and a 31% reduction in TPH2 protein levels, completely compensated after long-term treatment (14 days).
Negative_regulation (decrease) of Gene_expression (expression) of TPH2
1) Confidence 0.17 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.44 Pain Relevance 0.26

General Comments

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