INT338898

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTPN11) signal transduction (PECAM1) extracellular space (PECAM1)
cell adhesion (PECAM1) plasma membrane (PECAM1) cytoplasm (PTPN11)
Anatomy Link Frequency
platelet 2
PECAM1 (Homo sapiens)
PTPN11 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 73.76 Quite High
dexamethasone 2 67.76 Quite High
addiction 4 50.00 Quite Low
Kinase C 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Gabapentin 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
bradykinin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Purpura 2 71.28 Quite High
Thrombocytopenia 2 70.96 Quite High
Apoptosis 4 57.52 Quite High
Cancer 4 47.68 Quite Low
Targeted Disruption 2 5.72 Low Low
Cardiovascular Disease 24 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Renal Artery Obstruction 2 5.00 Very Low Very Low Very Low
Pre-eclampsia 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(no. 7) SHP-2 is a tyrosine phosphatase which binds to PECAM-1 [68] during the thrombin-induced platelet aggregation process [69].
PECAM-1 Binding (binds) of SHP-2 in platelet
1) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.20 Pain Relevance 0.10
(no. 8) SHP-1 is a splice variant of SHP-2, which binds with lesser affinity to PECAM-1 during platelet aggregation [70].
PECAM-1 Binding (binds) of SHP-2 in platelet
2) Confidence 0.03 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.18 Pain Relevance 0.10

General Comments

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