INT338931

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slco1b2) plasma membrane (Slco1b2) cytoplasm (Slco1b2)
Slco1b2 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 70 99.24 Very High Very High Very High
Bioavailability 1 51.08 Quite High
Arthritis 27 50.00 Quite Low
adenocard 8 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 22 98.52 Very High Very High Very High
Hepatotoxicity 1 80.12 Quite High
Targeted Disruption 2 59.20 Quite High
Disease 11 59.00 Quite High
Juvenile Chronic Polyarthritis 23 50.00 Quite Low
Rheumatoid Arthritis 11 41.92 Quite Low
Adverse Drug Reaction 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown to transport MTX in vitro [68], and in pediatric patients with ALL, variations in OATP1B1 were associated with clearance of MTX as well as GI toxicity [67].
OATP1B1 Binding (associated) of associated with toxicity and methotrexate
1) Confidence 0.05 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.47 Pain Relevance 0.39

General Comments

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