INT338936

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.08
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtx1)
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 70 100.00 Very High Very High Very High
Pain 27 63.88 Quite High
Arthritis 40 63.68 Quite High
visual analogue scale 3 51.36 Quite High
rheumatoid arthritis 3 50.00 Quite Low
Bioavailability 1 41.04 Quite Low
adenocard 8 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 22 98.88 Very High Very High Very High
Rheumatoid Arthritis 49 89.36 High High
Targeted Disruption 2 81.20 Quite High
Hepatotoxicity 1 70.08 Quite High
Pain 28 63.88 Quite High
Arthritis 15 63.68 Quite High
Juvenile Chronic Polyarthritis 23 50.00 Quite Low
Disease 20 48.96 Quite Low
Fatigue 15 38.00 Quite Low
Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In ABCC2-deficient rats, MTX biliary excretion was significantly reduced [69].
Negative_regulation (reduced) of Localization (excretion) of MTX associated with methotrexate
1) Confidence 0.30 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.47 Pain Relevance 0.37
Patients receiving CZP plus MTX reported less loss of productivity at home compared with placebo patients; this improvement began as early as Week 4 (first assessment), when CZP 200?
Negative_regulation (reported) of Localization (receiving) of MTX
2) Confidence 0.06 Published 2011 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC3021948 Disease Relevance 0.61 Pain Relevance 0.28

General Comments

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