INT338936

Context Info Confidence 0.30 First Reported 2010 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.08 Pain Relevance 0.64

mitochondrion (Mtx1)

Mtx1 (Mus musculus)

Pain Link Frequency Relevance Heat methotrexate 70 100.00 Pain 27 63.88 Arthritis 40 63.68 visual analogue scale 3 51.36 rheumatoid arthritis 3 50.00 Bioavailability 1 41.04 adenocard 8 5.00 withdrawal 4 5.00 Inflammation 2 5.00 Glutamate 2 5.00

Disease Link Frequency Relevance Heat Toxicity 22 98.88 Rheumatoid Arthritis 49 89.36 Targeted Disruption 2 81.20 Hepatotoxicity 1 70.08 Pain 28 63.88 Arthritis 15 63.68 Juvenile Chronic Polyarthritis 23 50.00 Disease 20 48.96 Fatigue 15 38.00 Infection 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In ABCC2-deficient rats, MTX biliary excretion was significantly reduced [69].

Negative_regulation (reduced) of Localization (excretion) of MTX associated with methotrexate

1) Confidence 0.30 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.47 Pain Relevance 0.37

Patients receiving CZP plus MTX reported less loss of productivity at home compared with placebo patients; this improvement began as early as Week 4 (first assessment), when CZP 200?

Negative_regulation (reported) of Localization (receiving) of MTX

2) Confidence 0.06 Published 2011 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC3021948 Disease Relevance 0.61 Pain Relevance 0.28

General Comments

This test has worked.