INT338940

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Fpgs, Mtx1) biosynthetic process (Fpgs) ligase activity (Fpgs)
cytoplasm (Fpgs)
Fpgs (Mus musculus)
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 70 100.00 Very High Very High Very High
antagonist 2 95.72 Very High Very High Very High
Glutamate 2 84.72 Quite High
Arthritis 27 50.00 Quite Low
adenocard 8 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 11 92.40 High High
Toxicity 22 89.40 High High
Body Weight 1 83.80 Quite High
Rheumatic Diseases 1 50.64 Quite High
Juvenile Chronic Polyarthritis 23 50.00 Quite Low
Adverse Drug Reaction 4 26.44 Quite Low
Death 1 6.88 Low Low
Cancer 2 6.16 Low Low
Disease 11 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once intracellular, MTX is bioactivated to a polyglutamated form by folylpolyglutamyl synthase (FPGS), which enhances the pharmacological activity and intracellular retention of MTX [29].
FPGS Positive_regulation (bioactivated) of MTX associated with methotrexate
1) Confidence 0.32 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.32 Pain Relevance 0.47

General Comments

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