INT338941

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ggh) mitochondrion (Mtx1) peptidase activity (Ggh)
extracellular space (Ggh) extracellular region (Ggh) lysosome (Ggh)
Ggh (Mus musculus)
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 70 100.00 Very High Very High Very High
Arthritis 27 63.60 Quite High
adenocard 8 17.60 Low Low
Inflammation 2 5.76 Low Low
Glutamate 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 22 100.00 Very High Very High Very High
Cancer 2 94.08 High High
Rheumatoid Arthritis 11 88.00 High High
Juvenile Chronic Polyarthritis 23 63.60 Quite High
Osteogenic Sarcomas 1 38.72 Quite Low
INFLAMMATION 2 5.76 Low Low
Disease 11 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, variations in GGH have shown conflicting associations with toxicity, however, a potential association with MTX response [33, 44].
GGH Binding (association) of MTX associated with toxicity and methotrexate
1) Confidence 0.30 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.47 Pain Relevance 0.27

General Comments

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