INT33895

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 2.47
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LIF) extracellular region (LIF)
Anatomy Link Frequency
DIA 2
brain 1
epithelium 1
mesoderm 1
foot 1
LIF (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 9 99.60 Very High Very High Very High
analgesia 7 96.96 Very High Very High Very High
opiate 12 95.60 Very High Very High Very High
withdrawal 1 92.16 High High
imagery 21 91.64 High High
agonist 13 91.56 High High
depression 4 91.28 High High
rapifen 4 82.40 Quite High
Analgesic 1 80.64 Quite High
anesthesia 5 77.04 Quite High
Disease Link Frequency Relevance Heat
Shock 6 100.00 Very High Very High Very High
Carcinoma 36 99.70 Very High Very High Very High
Leukemia 19 93.36 High High
Respiratory Failure 4 92.24 High High
Reprotox - General 3 21 72.72 Quite High
Cancer 84 71.52 Quite High
Metaplasia 16 60.52 Quite High
INFLAMMATION 56 50.00 Quite Low
Stress 5 47.84 Quite Low
Stress Incontinence 8 41.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two studies proposed that CLDN4 and LIF are upregulated by the action of progesterone [23,24].
Positive_regulation (upregulated) of LIF
1) Confidence 0.67 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
These data also re-emphasize the importance of LIF, as LIF+ immunolabeling is strongly associated with a higher chance of pregnancy, an outcome that is not affected by strong expression of CLDN4.
Positive_regulation (importance) of LIF
2) Confidence 0.49 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
and established a LIF-dependent STAT3 and ERK signaling that was comparable to the level observed in the carcinoma cells (Fig. 6).
Positive_regulation (established) of LIF associated with carcinoma
3) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.72 Pain Relevance 0.03
A similar FR901228 treatment of the carcinoma cells further enhanced LIFR expression and LIF-dependent signaling (Fig. 6).
Positive_regulation (enhanced) of LIF associated with carcinoma
4) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.60 Pain Relevance 0.03
While dexmedetomidine alone had minimal effects on DIA activity, it significantly attenuated the ALF-induced increase in expiratory DIA EMG.
Positive_regulation (increase) of DIA in DIA
5) Confidence 0.40 Published 1995 Journal Respir Physiol Section Abstract Doc Link 7624612 Disease Relevance 0.17 Pain Relevance 0.67
ALF produced a decrease in inspiratory and an increase in expiratory DIA EMG activity.
Positive_regulation (increase) of DIA in DIA
6) Confidence 0.40 Published 1995 Journal Respir Physiol Section Abstract Doc Link 7624612 Disease Relevance 0.17 Pain Relevance 0.74
However, controlled increase of endometrial LIF is not yet clinically possible.
Positive_regulation (increase) of LIF
7) Confidence 0.39 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.07 Pain Relevance 0
The activation of these receptors by their respective ligands (LIF and OSM, two members of the IL6 family) induces the interconversion between metanephros mesoderm and epithelium in the urinary tract [53,54].
Positive_regulation (activation) of LIF in mesoderm
8) Confidence 0.39 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.09 Pain Relevance 0
The activation of these receptors by their respective ligands (LIF and OSM, two members of the IL6 family) induces the interconversion between metanephros mesoderm and epithelium in the urinary tract [53,54].
Positive_regulation (activation) of LIF in epithelium
9) Confidence 0.13 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.09 Pain Relevance 0
Animals which had received 5 or 10 doses of THC in youth showed an enhanced response to foot-shock in the CDF rat.
Positive_regulation (enhanced) of CDF in foot associated with shock and delta-9-tetrahydrocannabinol
10) Confidence 0.04 Published 1986 Journal Neurobehav Toxicol Teratol Section Abstract Doc Link 3020462 Disease Relevance 0.56 Pain Relevance 0.76
m thickness) in near-adult murine brain (Figure 6), a setting where autofluorescence due to myelinization becomes an increasing problem for DiO, DiA and other 488 nm excited dyes (B.
Positive_regulation (increasing) of DiA in brain
11) Confidence 0.03 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0 Pain Relevance 0.11

General Comments

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