INT339

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2010
Negated 22
Speculated 41
Reported most in Abstract
Documents 156
Total Number 211
Disease Relevance 39.27
Pain Relevance 83.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
brain 19
striatum 9
hippocampus 8
neurons 8
blood 7
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1121 100.00 Very High Very High Very High
Morphine 265 100.00 Very High Very High Very High
Hippocampus 124 100.00 Very High Very High Very High
narcan 105 100.00 Very High Very High Very High
cocaine 88 100.00 Very High Very High Very High
Enkephalin 88 100.00 Very High Very High Very High
Nucleus accumbens 76 100.00 Very High Very High Very High
antagonist 73 100.00 Very High Very High Very High
opiate 69 100.00 Very High Very High Very High
Pain 65 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Congenital Anomalies 49 100.00 Very High Very High Very High
Stress 23 100.00 Very High Very High Very High
Nociception 13 100.00 Very High Very High Very High
Pain 47 99.96 Very High Very High Very High
Convulsion 33 99.96 Very High Very High Very High
Urological Neuroanatomy 125 99.52 Very High Very High Very High
Ataxia 5 99.48 Very High Very High Very High
Endotoxemia 1 99.20 Very High Very High Very High
Dyskinesias 544 99.16 Very High Very High Very High
Headache 7 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of single and repeated morphine administration on the level of thyrotropin-releasing hormone and its receptors in the rat brain.
Regulation (effects) of thyrotropin-releasing hormone in brain associated with morphine
1) Confidence 0.62 Published 1995 Journal Neuropeptides Section Title Doc Link 8837962 Disease Relevance 0 Pain Relevance 0.80
At 2 h after the last dose of repeated morphine, no significant changes in the TRH level were observed.
Neg (no) Regulation (changes) of TRH associated with morphine
2) Confidence 0.62 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837962 Disease Relevance 0 Pain Relevance 0.81
The effects of single and repeated administration of cocaine on the thyrotropin-releasing hormone (TRH) level and receptors in discrete rat brain structures were evaluated.
Regulation (effects) of thyrotropin-releasing hormone in brain structures associated with cocaine
3) Confidence 0.62 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9243522 Disease Relevance 0.08 Pain Relevance 0.29
The effects of single and repeated administration of cocaine on the thyrotropin-releasing hormone (TRH) level and receptors in discrete rat brain structures were evaluated.
Regulation (effects) of TRH in brain structures associated with cocaine
4) Confidence 0.62 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9243522 Disease Relevance 0.08 Pain Relevance 0.29
Effects of repeated cocaine administration on the thyrotropin-releasing hormone level and receptors in the rat brain.
Regulation (Effects) of thyrotropin-releasing hormone in brain associated with cocaine
5) Confidence 0.62 Published 1997 Journal Neuropeptides Section Title Doc Link 9243522 Disease Relevance 0.09 Pain Relevance 0.45
The influence of synthetic thyrotropin-releasing hormone (TRH) on locomotion, on the effects of analgetics, learning and memory, electrical activity of hypothalamic neurons, blood pressure, and cerebral circulation have been studied.
Regulation (influence) of TRH in blood
6) Confidence 0.62 Published 1983 Journal Biull Eksp Biol Med Section Abstract Doc Link 6412782 Disease Relevance 0.06 Pain Relevance 0.13
The influence of synthetic thyrotropin-releasing hormone (TRH) on locomotion, on the effects of analgetics, learning and memory, electrical activity of hypothalamic neurons, blood pressure, and cerebral circulation have been studied.
Regulation (influence) of synthetic thyrotropin-releasing hormone in blood
7) Confidence 0.62 Published 1983 Journal Biull Eksp Biol Med Section Abstract Doc Link 6412782 Disease Relevance 0.06 Pain Relevance 0.13
Extracellular recording method was used to examine the effect of thyrotropin-releasing hormone (TRH) on 71 unit discharges of pain-excited neurons (PEN) in mesencephalic reticular formation (MRF) in 58 rats.
Spec (examine) Regulation (effect) of thyrotropin-releasing hormone in reticular formation associated with pain
8) Confidence 0.62 Published 1989 Journal J. Tongji Med. Univ. Section Abstract Doc Link 2517132 Disease Relevance 0.33 Pain Relevance 0.37
Extracellular recording method was used to examine the effect of thyrotropin-releasing hormone (TRH) on 71 unit discharges of pain-excited neurons (PEN) in mesencephalic reticular formation (MRF) in 58 rats.
Spec (examine) Regulation (effect) of TRH in reticular formation associated with pain
9) Confidence 0.62 Published 1989 Journal J. Tongji Med. Univ. Section Abstract Doc Link 2517132 Disease Relevance 0.33 Pain Relevance 0.38
The changes in preproTRH mRNA are accompanied by changes in TRH peptide
Regulation (changes) of preproTRH
10) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.35 Pain Relevance 0.18
The changes in preproTRH mRNA are accompanied by changes in TRH peptide
Regulation (changes) of TRH peptide
11) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.35 Pain Relevance 0.18
This selectivity suggests that the TRH dysregulation strongly affected the sensorimotor striatum and nearby regions.
Regulation (dysregulation) of TRH in striatum
12) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.11 Pain Relevance 0.14
The influence of thyrotropin-releasing hormone (TRH) on morphine-induced analgesic and reinforced responses was studied in two inbred strains of rats, Fischer-344 (F344) and Wistar Albino Glaxo/GSto (WAG).
Regulation (influence) of thyrotropin-releasing hormone associated with analgesic, sprains and strains and morphine
13) Confidence 0.62 Published 1995 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 8585307 Disease Relevance 0.22 Pain Relevance 0.83
The influence of thyrotropin-releasing hormone (TRH) on morphine-induced analgesic and reinforced responses was studied in two inbred strains of rats, Fischer-344 (F344) and Wistar Albino Glaxo/GSto (WAG).
Regulation (influence) of TRH associated with analgesic, sprains and strains and morphine
14) Confidence 0.62 Published 1995 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 8585307 Disease Relevance 0.22 Pain Relevance 0.83
Chronic exposure to hypergravity affects thyrotropin-releasing hormone levels in rat brainstem and cerebellum.
Regulation (affects) of thyrotropin-releasing hormone in brainstem associated with medulla and neuropeptide
15) Confidence 0.62 Published 1998 Journal Biol Signals Recept Section Title Doc Link 9873155 Disease Relevance 0 Pain Relevance 0.77
[Effect of amygdaloid kindling on thyrotropin-releasing hormone, somatostatin, cholecystokinin and substance P contents of the amygdala/piriform cortex and hippocampus of rats].
Regulation (Effect) of thyrotropin-releasing hormone in hippocampus associated with somatostatin, hippocampus, amygdala, cholecystokinin and substance p
16) Confidence 0.61 Published 1988 Journal No To Shinkei Section Title Doc Link 2465012 Disease Relevance 0.32 Pain Relevance 0.83
Thus, these results demonstrate a region-specific regulation of TRH prohormone processing in the brain, which may engage PC2, further suggesting a role for specific proTRH-derived peptides in the manifestations of opiate withdrawal.
Regulation (regulation) of TRH prohormone in brain associated with opiate and withdrawal
17) Confidence 0.61 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 11948251 Disease Relevance 0.41 Pain Relevance 0.87
The effects of bilateral olfactory bulbectomy (OBX) on prepro-enkephalin, thyrotropin-releasing hormone, and D-2 receptor mRNA levels in the ventral striatum were examined by in situ hybridization histochemistry.
Spec (examined) Regulation (effects) of thyrotropin-releasing hormone in ventral associated with enkephalin
18) Confidence 0.60 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657493 Disease Relevance 0 Pain Relevance 0.42
No changes in TRH mRNA could be detected after reserpine of colchicine.
Neg (No) Regulation (changes) of TRH mRNA
19) Confidence 0.59 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1850078 Disease Relevance 0 Pain Relevance 0.41
The present results show that, in addition to TRH mRNA, other hypothalamic peptide mRNAs are affected by thyroid hormone levels.
Regulation (affected) of TRH mRNA in thyroid
20) Confidence 0.59 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1283206 Disease Relevance 0.28 Pain Relevance 0.20

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