INT339003

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.37
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (ST13) protein folding (ST13) cytosol (ST13)
protein binding, bridging (ST13) protein complex (ST13) cytoplasm (ST13)
Anatomy Link Frequency
SNc 2
spinal 1
ST13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Ventral tegmentum 28 100.00 Very High Very High Very High
Hippocampus 10 86.44 High High
amygdala 2 85.80 High High
midbrain 22 85.04 High High
Nucleus accumbens 14 83.08 Quite High
Dopamine 140 72.96 Quite High
Substantia nigra 2 61.40 Quite High
cocaine 14 5.00 Very Low Very Low Very Low
addiction 14 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 2 96.44 Very High Very High Very High
Cancer 2 91.24 High High
Shock 28 73.96 Quite High
Cataract 2 50.84 Quite High
Clinical Trials And Case Reports 2 50.00 Quite Low
Embryonic Lethality 2 32.00 Quite Low
Targeted Disruption 6 30.60 Quite Low
Disease 38 5.00 Very Low Very Low Very Low
Stress 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of Hspabp was shown to decrease inclusion formation in an cell culture model of spinal and bulbar muscular atrophy [87].
Gene_expression (Overexpression) of Hspabp in spinal associated with muscular atrophy
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.30 Pain Relevance 0.03
Hspa8 and Hspabp are both ubiquitously expressed at high levels, suggesting Hspa8 is usually stably holding client proteins in an ADP-bound state.
Gene_expression (expressed) of Hspabp
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.07 Pain Relevance 0.03
In human brain, there are relatively few neurons in the SNc and VTA (less than 400,000 in the SNc and roughly 5,000 in the VTA [16,23]).
Gene_expression (400,000) of SNc in SNc associated with ventral tegmentum
3) Confidence 0.07 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2958859 Disease Relevance 0 Pain Relevance 0.59
In human brain, there are relatively few neurons in the SNc and VTA (less than 400,000 in the SNc and roughly 5,000 in the VTA [16,23]).
Gene_expression (400,000) of SNc in SNc associated with ventral tegmentum
4) Confidence 0.07 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2958859 Disease Relevance 0 Pain Relevance 0.59

General Comments

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