INT339011

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fmr1) RNA binding (Fmr1) nucleus (Fmr1)
cytoplasm (Fmr1)
Fmr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 30.48 Quite Low
visual analogue scale 14 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 96 90.64 High High
Intellectual Impairment 4 86.68 High High
Aggression 10 82.76 Quite High
Attention Deficit Hyperactivity Disorder 14 82.12 Quite High
Convulsion 12 73.04 Quite High
Learning Disorders 2 71.44 Quite High
Cognitive Disorder 16 70.32 Quite High
Autism 12 66.28 Quite High
Fragile X Syndrome 2 62.92 Quite High
Targeted Disruption 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When of sufficient size, these expansions cause promoter methylation and gene silencing, resulting in the absence of, or reduced levels of FMR1 mRNA and FMRP (the protein product of FMR1).
Negative_regulation (reduced) of Positive_regulation (levels) of FMR1
1) Confidence 0.43 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2958860 Disease Relevance 1.09 Pain Relevance 0
When of sufficient size, these expansions cause promoter methylation and gene silencing, resulting in the absence of, or reduced levels of FMR1 mRNA and FMRP (the protein product of FMR1).
Negative_regulation (reduced) of Positive_regulation (levels) of FMRP
2) Confidence 0.43 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2958860 Disease Relevance 1.09 Pain Relevance 0

General Comments

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