INT339020

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SERPINA1, ELANE) peptidase activity (ELANE) extracellular space (SERPINA1)
proteinaceous extracellular matrix (SERPINA1) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophil 1
SERPINA1 (Homo sapiens)
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 96.68 Very High Very High Very High
Potency 23 5.00 Very Low Very Low Very Low
spinal stenosis 1 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 3 97.24 Very High Very High Very High
INFLAMMATION 1 96.68 Very High Very High Very High
Emphysema 3 92.40 High High
Disease 2 82.72 Quite High
Autosomal Disorder 1 76.40 Quite High
Disease Progression 1 58.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 Very Low Very Low Very Low
Hepatitis 3 5.00 Very Low Very Low Very Low
Pulmonary Disease 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neutrophil elastase is normally inactivated by alpha1-PI and the lung is protected, but in individuals with a deficiency of alpha1-PI, neutrophil elastase may cause irreversible destruction of pulmonary structures resulting in the development of emphysema.
alpha1-PI Negative_regulation (inactivated) of elastase in neutrophil associated with emphysema
1) Confidence 0.07 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2958874 Disease Relevance 0.59 Pain Relevance 0.05

General Comments

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