INT339058

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.13
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fbn1) proteinaceous extracellular matrix (Fbn1)
Fbn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nud 3 66.08 Quite High
Angina 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 75 99.52 Very High Very High Very High
Malignant Neoplastic Disease 15 99.12 Very High Very High Very High
Aortic Aneurysms 42 98.52 Very High Very High Very High
Marfan Syndrome 78 97.56 Very High Very High Very High
Aortic Disease 3 94.56 High High
Catastrophic Illness 3 85.84 High High
Aneurism 27 84.76 Quite High
Patent Ductus Arteriosus 3 76.40 Quite High
Injury 3 75.76 Quite High
Hypertension 3 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding suggests that autosomal dominant non-syndromic TAAD may be associated with FBN1 gene mutation and implicates the necessity of echocardiographic screening of the relatives of patients with familial TAAD.
FBN1 Binding (associated) of
1) Confidence 0.48 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958900 Disease Relevance 1.42 Pain Relevance 0
Association between FBN1 mutation and familial non-syndromic aortic aneurysm has been previously reported [19].
FBN1 Binding (Association) of associated with aortic aneurysms
2) Confidence 0.35 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958900 Disease Relevance 1.03 Pain Relevance 0
A familial non-syndromic TAAD is strongly associated with the FBN1 gene locus and has a malignant disease course often seen in MFS patients.
FBN1 Binding (associated) of associated with malignant neoplastic disease, marfan syndrome and disease
3) Confidence 0.35 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2958900 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

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