INT339072

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.76
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
spinal cord 2
Eae1 (Mus musculus)
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 60 98.92 Very High Very High Very High
Demyelination 6 94.84 High High
COX2 12 72.40 Quite High
Inflammation 66 57.28 Quite High
Inflammatory mediators 4 55.84 Quite High
Multiple sclerosis 52 5.00 Very Low Very Low Very Low
Central nervous system 20 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 264 100.00 Very High Very High Very High
Stress 154 100.00 Very High Very High Very High
Demyelinating Disease 10 94.84 High High
Urological Neuroanatomy 20 74.84 Quite High
INFLAMMATION 72 57.28 Quite High
Immunization 4 44.96 Quite Low
Autoimmune Disease 2 17.44 Low Low
Disease 46 5.00 Very Low Very Low Very Low
Central Nervous System Disease 18 5.00 Very Low Very Low Very Low
Paralysis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EAE and stress increase expression of iNOS (figure 6B: F: 26,53, dF: 7) and, although there is a trend toward the iNOS increase in expression to be higher in the EAE+S group, there are no statistical differences when compared to the EAE group.
EAE Positive_regulation (increase) of Gene_expression (expression) of iNOS associated with stress and multiple sclerosis
1) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.56 Pain Relevance 0.21
Both EAE and chronic stress induced an increase in iNOS expression compared with the control group in spinal cord homogenates, as measured by western blot.
EAE Positive_regulation (increase) of Gene_expression (expression) of iNOS in spinal cord associated with stress, multiple sclerosis and spinal cord
2) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 2.20 Pain Relevance 0.38

General Comments

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