INT339091

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Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 11.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Ezh2) chromosome (Ezh2) nucleus (Ezh2)
DNA binding (Ezh2)
Anatomy Link Frequency
liver 4
kidney 2
stomach 1
endometrium 1
Ezh2 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 9 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 162 99.68 Very High Very High Very High
Renal Cancer 495 99.52 Very High Very High Very High
Breast Cancer 63 98.76 Very High Very High Very High
Cancer 450 98.70 Very High Very High Very High
Skin Cancer 27 98.46 Very High Very High Very High
Prostate Cancer 27 94.88 High High
Hepatocellular Cancer 9 93.36 High High
Endometrial Cancer 9 86.64 High High
Carcinoma 18 82.48 Quite High
Apoptosis 18 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased EZH2 expression in tumorous versus corresponding normal tissue has been also reported for other cancers as well, including malignant melanoma, prostate carcinoma, breast cancer and hepatocellular carcinoma [7,9,17,37].
Positive_regulation (Increased) of Gene_expression (expression) of EZH2 associated with cancer, hepatocellular cancer, breast cancer, prostate cancer and skin cancer
1) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.40 Pain Relevance 0
Overexpression of EZH2 conferred cellular growth advantage in vitro [6,7], promoted invasion [7], and exhibited oncogenic properties in nude mice [8].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of EZH2
2) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.15 Pain Relevance 0
Our results are in line with studies in several other tumor forms, including malignant melanoma and cancers of the breast, prostate, endometrium, stomach, and liver, where increased EZH2 expression has been linked to more aggressive tumor behaviour and poor prognosis [7,9,17,36,37].
Positive_regulation (increased) of Gene_expression (expression) of EZH2 in liver associated with cancer and skin cancer
3) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.23 Pain Relevance 0
RCCs exhibited significantly higher EZH2 expression levels than histologically normal kidney, indicating that an increase in EZH2 expression is acquired during RCC tumorigenesis.
Positive_regulation (increase) of Gene_expression (expression) of EZH2 in kidney associated with renal cancer
4) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.43 Pain Relevance 0
Under diagnostic aspects, it is noteworthy that upregulation of EZH2 expression can be detected very early in breast cancer development, even before atypic cells are histologically evident [15,16].
Positive_regulation (upregulation) of Gene_expression (expression) of EZH2 associated with breast cancer
5) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.03 Pain Relevance 0
Moreover, high nuclear EZH2 expression in non-metastatic disease, and nuclear EZH2 expression in metastatic disease are unfavourable independent predictive parameters of CSS.
Positive_regulation (nuclear) of Gene_expression (expression) of EZH2 associated with metastasis
6) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.39 Pain Relevance 0
We show that EZH2 is significantly overexpressed in primary RCC, when compared with histologically normal renal tissue.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EZH2 associated with renal cancer
7) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.55 Pain Relevance 0
Our results are in line with studies in several other tumor forms, including malignant melanoma and cancers of the breast, prostate, endometrium, stomach, and liver, where increased EZH2 expression has been linked to more aggressive tumor behaviour and poor prognosis [7,9,17,36,37].
Positive_regulation (increased) of in endometrium Gene_expression (expression) of EZH2 in liver associated with cancer and skin cancer
8) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.23 Pain Relevance 0
Our results are in line with studies in several other tumor forms, including malignant melanoma and cancers of the breast, prostate, endometrium, stomach, and liver, where increased EZH2 expression has been linked to more aggressive tumor behaviour and poor prognosis [7,9,17,36,37].
Positive_regulation (increased) of in stomach Gene_expression (expression) of EZH2 in liver associated with cancer and skin cancer
9) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.23 Pain Relevance 0

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