INT339092

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Rcc1) chromosome segregation (Rcc1) histone binding (Rcc1)
nucleus (Rcc1) cell cycle (Rcc1) DNA binding (Rcc1)
Rcc1 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 330 100.00 Very High Very High Very High
Cancer 300 99.28 Very High Very High Very High
Breast Cancer 42 97.36 Very High Very High Very High
Apoptosis 12 97.20 Very High Very High Very High
Death 42 96.68 Very High Very High Very High
Reprotox - General 1 6 96.16 Very High Very High Very High
Prostate Cancer 18 94.88 High High
Metastasis 108 71.92 Quite High
Hepatocellular Cancer 6 70.68 Quite High
Skin Cancer 18 68.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apart form serving as a novel prognostic marker in RCC, EZH2 expression may also have therapeutic and diagnostic implications.
Gene_expression (expression) of RCC associated with renal cancer
1) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.02 Pain Relevance 0
We recently found that inhibition of endogenous EZH2 expression in RCC cell lines by RNAi was linked to reduced proliferation and increased apoptosis in RCC [13] and cervical carcinoma cells [14].
Gene_expression (expression) of RCC associated with renal cancer, apoptosis and reprotox - general 1
2) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.36 Pain Relevance 0
Multivariate Cox regression analyses on RCC outcome included tumor stage, Fuhrman's grading, Karnofsky performance status, age, sex, histopathological subtype, and EZH2 expression.
Spec (analyses) Gene_expression (regression) of RCC associated with cancer and renal cancer
3) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.20 Pain Relevance 0
I), Fuhrman's grade (grade 2, 3/4 vs. 1), histopathological subtype (clear cell RCC vs. other types), nuclear EZH2 expression (1-5%, >5-25%, >25-50%, >50% vs. 0%).


Gene_expression (expression) of RCC associated with renal cancer
4) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 0.85 Pain Relevance 0
In a subgroup of patients with metastatic RCC (n = 51), we included EZH2 expression and the Motzer criteria as the only two factors in a multivariate cox proportional hazards model, which reviewed EZH2 as a borderline significant factor, despite the small number of patients in the analyses (data not shown).
Gene_expression (expression) of RCC associated with renal cancer
5) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 0.90 Pain Relevance 0
For metastasized RCC, 1-5%, >5-25%, and >25-50% nuclear EZH2 expression was linked to decreased CSS when compared with tumors with undetectable EZH2 expression (HR 2.63, p = 0.043, HR 3.35, p = 0.013, HR 4.92, p = 0.003).
Gene_expression (expression) of RCC associated with cancer and renal cancer
6) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.04 Pain Relevance 0

General Comments

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