INT339095

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Ezh2) chromosome (Ezh2) nucleus (Ezh2)
DNA binding (Ezh2)
Anatomy Link Frequency
apoptotic cell 2
Ezh2 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 220 99.84 Very High Very High Very High
Cancer 200 98.92 Very High Very High Very High
Breast Cancer 28 98.56 Very High Very High Very High
Death 28 97.88 Very High Very High Very High
Apoptosis 8 97.44 Very High Very High Very High
Prostate Cancer 12 96.08 Very High Very High Very High
Reprotox - General 1 4 95.88 Very High Very High Very High
Hepatocellular Cancer 4 91.80 High High
Skin Cancer 12 89.24 High High
Urinary Tract Cancer 4 63.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently found that inhibition of endogenous EZH2 expression in RCC cell lines by RNAi was linked to reduced proliferation and increased apoptosis in RCC [13] and cervical carcinoma cells [14].
Negative_regulation (inhibition) of Gene_expression (expression) of EZH2 associated with renal cancer, apoptosis and reprotox - general 1
1) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.37 Pain Relevance 0
Vice versa, inhibition of EZH2 expression by antisense constructs or RNA interference (RNAi) resulted in growth inhibition of cancer cells [9,10], and induced anoikis in circulating prostate carcinoma precursor cells [11] or apoptotic cell death in breast cancer cells [12].
Negative_regulation (inhibition) of Gene_expression (expression) of EZH2 in apoptotic cell associated with cancer, breast cancer, prostate cancer, apoptosis and death
2) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.30 Pain Relevance 0
The high proportion of RCCs showing increased EZH2 protein levels may also have therapeutic implications, since targeted inhibition of EZH2 expression has been shown to repress tumor cell growth.


Negative_regulation (inhibition) of Gene_expression (expression) of EZH2 associated with cancer
3) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 0.75 Pain Relevance 0
This indicates that detectable EZH2 expression is not stringently restricted to tumor cells.
Negative_regulation (detectable) of Gene_expression (expression) of EZH2 associated with cancer
4) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958940 Disease Relevance 1.06 Pain Relevance 0

General Comments

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