INT33915

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Context Info
Confidence 0.60
First Reported 1986
Last Reported 2010
Negated 6
Speculated 2
Reported most in Abstract
Documents 22
Total Number 24
Disease Relevance 2.44
Pain Relevance 16.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
medulla 4
striatum 4
NG108-15 3
P19 2
plasma 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 143 100.00 Very High Very High Very High
opioid receptor 74 100.00 Very High Very High Very High
Opioid 25 100.00 Very High Very High Very High
Ventral tegmentum 8 99.98 Very High Very High Very High
Neuropeptide 3 99.98 Very High Very High Very High
Inflammation 6 99.90 Very High Very High Very High
Morphine 53 99.64 Very High Very High Very High
Enkephalin 25 99.64 Very High Very High Very High
Analgesic 13 99.64 Very High Very High Very High
narcan 7 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 99.90 Very High Very High Very High
Insulin Resistance 1 99.56 Very High Very High Very High
Embryonal Carcinoma 1 99.04 Very High Very High Very High
Cancer 2 97.20 Very High Very High Very High
Necrosis 2 96.96 Very High Very High Very High
Targeted Disruption 14 94.48 High High
Death 1 94.40 High High
Drug Dependence 2 87.76 High High
Inflammatory Pain 3 84.12 Quite High
Pain 2 76.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether deltaOR trafficking induced by chronic inflammation was dependent on the activation of muOR, we investigated by immunogold cytochemistry the effects of intraplantar CFA injection on the plasma membrane density of deltaOR in muOR knockout (KO) mice.
Regulation (dependent) of Positive_regulation (activation) of muOR in plasma associated with targeted disruption and inflammation
1) Confidence 0.60 Published 2004 Journal Pain Section Abstract Doc Link 15157687 Disease Relevance 0.60 Pain Relevance 0.61
These findings suggest that MOR activation by endogenous and/or exogenous MOR-selective opioid substances differentially regulates the activities of the striosome and matrix compartments and thus plays an important role in motivated behavior and learning.
Regulation (regulates) of Positive_regulation (activation) of MOR associated with opioid receptor and opioid
2) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17804632 Disease Relevance 0.06 Pain Relevance 0.62
Truncation of the mu receptor by removal of its carboxyl terminus at Glu341 did not affect the ability of the fentanyl analogs to bind to and activate the mu receptor nor did it prevent the fentanyl analogs from desensitizing the receptor.
Neg (not) Regulation (affect) of Neg (nor) Positive_regulation (activate) of mu receptor
3) Confidence 0.45 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618424 Disease Relevance 0.07 Pain Relevance 0.66
The present study examined the effect of in vivo antisense oligodeoxynucleotide treatment on naltrexone (NTX)-induced functional supersensitivity and mu-opioid receptor up-regulation in mice.
Spec (examined) Regulation (effect) of Positive_regulation (up-regulation) of mu-opioid receptor associated with opioid receptor
4) Confidence 0.43 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9128924 Disease Relevance 0 Pain Relevance 0.38
Our laboratory and others have demonstrated that MOR promoter activity is regulated by many enhancer elements and their related transcriptional factors such as SOX, SP1, AP2, NF-?
Regulation (regulated) of Positive_regulation (activity) of MOR promoter associated with mu opioid receptor
5) Confidence 0.40 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.06 Pain Relevance 0.69
The neutral antagonist 6 beta-naltrexol blocked MOR activation without affecting basal signaling (G protein coupling and adenylyl cyclase regulation) and also elicited substantially less severe withdrawal.
Neg (without) Regulation (affecting) of Positive_regulation (activation) of MOR associated with antagonist and withdrawal
6) Confidence 0.39 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600246 Disease Relevance 0.13 Pain Relevance 1.07
However, the induction of MOR sensitization was not modified by any doses of MK-801, except for the case of combination of MOR (20 mg/kg) with MK-801 (1 mg/kg) which was highly toxic (i.e., eliciting death or a moribund condition).
Neg (not) Regulation (modified) of Positive_regulation (induction) of MOR associated with death
7) Confidence 0.27 Published 1996 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 8640458 Disease Relevance 0.09 Pain Relevance 0.20
When NTX and oligodeoxynucleotide treatments were combined, there was no change in NTX-induced supersensitivity and mu-opioid receptor upregulation.
Neg (no) Regulation (change) of Positive_regulation (upregulation) of mu-opioid receptor associated with opioid receptor
8) Confidence 0.26 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9128924 Disease Relevance 0 Pain Relevance 1.48
Gene expression is altered in the lateral hypothalamus upon activation of the mu opioid receptor.
Regulation (altered) of in lateral Positive_regulation (activation) of mu opioid receptor in hypothalamus associated with mu opioid receptor
9) Confidence 0.25 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 18591478 Disease Relevance 0.22 Pain Relevance 0.37
An attempt has been made to identify minimal structural elements responsible for the mu-receptor activation.
Regulation (responsible) of Positive_regulation (activation) of mu-receptor
10) Confidence 0.22 Published 1986 Journal Bioorg. Khim. Section Abstract Doc Link 3021174 Disease Relevance 0 Pain Relevance 1.48
The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitoring the guanosine-5'-o-(3-[(35)S]thio) triphosphate ([(35)S]GTP gamma S) binding assay.
Regulation (affect) of Positive_regulation (activation) of mu-opioid receptor in medulla associated with medulla, kinase c, opioid receptor and spinal cord
11) Confidence 0.15 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.12 Pain Relevance 0.68
These data suggest that opiates active at MOR in the VTA modulate cortical activity through 1) presynaptic actions on MOR in terminals contacting mesocortical cell bodies, and 2) direct activation of MOR in distal dendrites of projection neurons.
Regulation (modulate) of Positive_regulation (activation) of MOR in dendrites associated with ventral tegmentum, mu opioid receptor, projection neuron and opiate
12) Confidence 0.14 Published 2001 Journal Synapse Section Abstract Doc Link 11418935 Disease Relevance 0 Pain Relevance 0.86
Here we have used a genome-wide microarray approach to identify LH responses to chronic mu opioid receptor activation at the transcriptional level.
Regulation (responses) of Positive_regulation (activation) of mu opioid receptor associated with mu opioid receptor
13) Confidence 0.11 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18591478 Disease Relevance 0.24 Pain Relevance 0.39
Furthermore, chronic administration of naltrexone did not result in changes of MOR mRNA levels in rat striatum of naive and morphine-dependent rats, suggesting that the up-regulation of the MOR density, at least in this tissue, is not regulated at transcriptional level.
Neg (not) Regulation (regulated) of Positive_regulation (up-regulation) of MOR in striatum associated with opioid receptor and morphine
14) Confidence 0.11 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9105683 Disease Relevance 0 Pain Relevance 1.03
Consequently, the manifestation of specific adenylyl cyclase (AC)-related neurochemical sequelae of long-term morphine treatment should depend on the consequences of short-term mu-opioid receptor (MOR) activation.
Regulation (depend) of Positive_regulation (activation) of MOR associated with opioid receptor and morphine
15) Confidence 0.07 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18045853 Disease Relevance 0 Pain Relevance 0.85
The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitoring the guanosine-5'-o-(3-[(35)S]thio) triphosphate ([(35)S]GTP gamma S) binding assay.
Regulation (affect) of in spinal cord Positive_regulation (activation) of mu-opioid receptor in medulla associated with medulla, kinase c, opioid receptor and spinal cord
16) Confidence 0.05 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.12 Pain Relevance 0.68
The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitoring the guanosine-5'-o-(3-[(35)S]thio) triphosphate ([(35)S]GTP gamma S) binding assay.
Regulation (affect) of in pons Positive_regulation (activation) of mu-opioid receptor in medulla associated with medulla, kinase c, opioid receptor and spinal cord
17) Confidence 0.05 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.12 Pain Relevance 0.68
Expression of the MOR is up-regulated during neuronal differentiation in P19 embryonal carcinoma cells and epigenetic changes play an important role in MOR up-regulation.
Regulation (role) of Positive_regulation (up-regulation) of MOR in P19 associated with mu opioid receptor and embryonal carcinoma
18) Confidence 0.05 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20385708 Disease Relevance 0.10 Pain Relevance 0.37
Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes.
Regulation (effects) of Positive_regulation (activation) of mu receptor in NG108-15 associated with analgesic and opioid
19) Confidence 0.03 Published 1997 Journal J. Neurochem. Section Title Doc Link 9084416 Disease Relevance 0 Pain Relevance 0.87
Neuropeptides regulate striatal cholinergic transmission and particularly activation of mu opioid receptor (MOR) inhibits acetylcholine (ACh) release in the dorsal striatum.
Regulation (regulate) of Positive_regulation (activation) of MOR in striatum associated with mu opioid receptor and neuropeptide
20) Confidence 0.02 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16026468 Disease Relevance 0 Pain Relevance 0.46

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