INT339178

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MIEN1) plasma membrane (MIEN1) cytoplasm (MIEN1)
MIEN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 87 5.00 Very Low Very Low Very Low
Neuropathic pain 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 240 97.88 Very High Very High Very High
Breast Cancer 72 96.44 Very High Very High Very High
Lobular Carcinoma 3 92.52 High High
Skin Cancer 3 9.60 Low Low
INFLAMMATION 87 5.00 Very Low Very Low Very Low
Metastasis 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amplification and overexpression of other genes (such as GRB7, C17orf37 and STARD3) of the 17q12 region could contribute to tumor growth [18,19].
Gene_expression (overexpression) of C17orf37 associated with cancer
1) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.31 Pain Relevance 0
C17ORF37 protein expression is linked with ERBB2-amplification in most cases, however, it has also been observed in breast carcinomas that do not overexpress ERBB2, and particularly in early stage and infiltrating lobular carcinomas that typically do not overexpress ERBB2 [49].
Gene_expression (expression) of C17ORF37 protein associated with breast cancer and lobular carcinoma
2) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.41 Pain Relevance 0
In the 17q12-q21.2 amplicon, which exhibited the highest frequency (Additionnal file 1-Tables S6A-S6B), amplifications combined to the upregulated gene expression of CRKRS (71%), STARD3 (82%), PERLD1 (86%), ERBB2 (92%), C17orf37 (84%) and GRB7 (86%) were the most frequent (Additionnal file 1-Tables S6A-S6B).
Gene_expression (expression) of C17orf37
3) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.14 Pain Relevance 0

General Comments

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