INT339199

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.30
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (GRB7) cytosol (GRB7) signal transduction (GRB7)
RNA binding (GRB7) plasma membrane (GRB7) cytoplasm (GRB7)
GRB7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 116 93.84 High High
Neuropathic pain 4 23.36 Low Low
depression 4 22.64 Low Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 320 97.48 Very High Very High Very High
INFLAMMATION 116 93.84 High High
Breast Cancer 96 78.00 Quite High
Lobular Carcinoma 4 70.16 Quite High
Neuropathic Pain 4 23.36 Low Low
Depression 4 22.64 Low Low
Injury 4 21.04 Low Low
Stress 8 20.60 Low Low
Metastasis 12 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amplification and overexpression of other genes (such as GRB7, C17orf37 and STARD3) of the 17q12 region could contribute to tumor growth [18,19].
Gene_expression (overexpression) of GRB7 associated with cancer
1) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.31 Pain Relevance 0
MLLT6, CISD3, PCGF2, PSMB3, PIP4K2B, FBXL20, STARD3, GRB7 were gained or amplified in both populations.
Gene_expression (gained) of GRB7
2) Confidence 0.54 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.43 Pain Relevance 0.18
MLLT6, CISD3, PCGF2, PSMB3, PIP4K2B, FBXL20, STARD3, GRB7 were gained or amplified in both populations.
Gene_expression (amplified) of GRB7
3) Confidence 0.54 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.43 Pain Relevance 0.18
In the 17q12-q21.2 amplicon, which exhibited the highest frequency (Additionnal file 1-Tables S6A-S6B), amplifications combined to the upregulated gene expression of CRKRS (71%), STARD3 (82%), PERLD1 (86%), ERBB2 (92%), C17orf37 (84%) and GRB7 (86%) were the most frequent (Additionnal file 1-Tables S6A-S6B).
Gene_expression (expression) of GRB7
4) Confidence 0.54 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.14 Pain Relevance 0

General Comments

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