INT3392

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 23
Total Number 25
Disease Relevance 8.21
Pain Relevance 15.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
brain 3
neurons 3
colon 2
spinal cord 1
striatum 1
Sst (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 151 100.00 Very High Very High Very High
substance P 36 100.00 Very High Very High Very High
GABAergic 19 100.00 Very High Very High Very High
Enkephalin 11 100.00 Very High Very High Very High
bradykinin 3 99.88 Very High Very High Very High
Mexiletine 6 99.72 Very High Very High Very High
opiate 6 99.68 Very High Very High Very High
narcan 10 99.54 Very High Very High Very High
Pain 3 99.54 Very High Very High Very High
antagonist 47 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 17 100.00 Very High Very High Very High
Stress 19 99.98 Very High Very High Very High
Aging 10 99.84 Very High Very High Very High
Bordatella Infection 1 99.66 Very High Very High Very High
Congenital Anomalies 1 99.58 Very High Very High Very High
Disease 268 99.44 Very High Very High Very High
Infection 10 99.32 Very High Very High Very High
Ulcers 10 98.24 Very High Very High Very High
Cognitive Disorder 20 97.48 Very High Very High Very High
Targeted Disruption 40 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 8 weeks of infection with S. mansoni, this inhibitory effect of somatostatin was less pronounced and after 16 weeks of infection it was completely abolished.
Negative_regulation (effect) of somatostatin associated with somatostatin and infection
1) Confidence 0.59 Published 2002 Journal Int. J. Parasitol. Section Abstract Doc Link 12204231 Disease Relevance 1.06 Pain Relevance 0.42
In contrast, the effects of SRIF were abolished completely by naloxone (0.2 mg/kg) but not methyl-naloxone (0.3 mg/kg) given systemically.
Neg (not) Negative_regulation (abolished) of SRIF associated with narcan and somatostatin
2) Confidence 0.49 Published 1987 Journal Peptides Section Abstract Doc Link 2888098 Disease Relevance 0 Pain Relevance 0.87
I.t. administration of somatostatin (SOM) antiserum, cysteamine, a relatively selective depletor of SOM and cyclo-SOM, a SOM receptor antagonist, produced no inhibitory effect on the morphine-induced behaviour.
Negative_regulation (depletor) of SOM associated with antagonist, somatostatin and morphine
3) Confidence 0.42 Published 1996 Journal Brain Res. Section Abstract Doc Link 8828571 Disease Relevance 0 Pain Relevance 1.61
In contrast, the numbers of cholinergic, GABAergic, and somatostatin-containing interneurons in the ischemic striatum were not different from those in the contralateral hemisphere at 3 and 14 days.
Negative_regulation (numbers) of somatostatin in striatum associated with gabaergic and somatostatin
4) Confidence 0.42 Published 2003 Journal Brain Pathol. Section Abstract Doc Link 14655751 Disease Relevance 0.23 Pain Relevance 0.54
Cold water swim stress inhibits the nociceptive responses to intrathecally administered somatostatin, but not substance P.
Negative_regulation (inhibits) of somatostatin associated with nociception, stress, narcan, somatostatin and substance p
5) Confidence 0.41 Published 1993 Journal Life Sci. Section Title Doc Link 7681927 Disease Relevance 1.06 Pain Relevance 0.88
In the colon, while SST inhibited the carbachol induced increase in I(sc), pre-treatment with tetrodotoxin (750 nM) profoundly inhibited the carbachol induced increase in I(sc), thus markedly reducing the inhibitory effect of SST.
Negative_regulation (effect) of SST in colon associated with tetrodotoxin
6) Confidence 0.38 Published 2000 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 10840221 Disease Relevance 0 Pain Relevance 0.17
In the colon, while SST inhibited the carbachol induced increase in I(sc), pre-treatment with tetrodotoxin (750 nM) profoundly inhibited the carbachol induced increase in I(sc), thus markedly reducing the inhibitory effect of SST.
Negative_regulation (reducing) of SST in colon associated with tetrodotoxin
7) Confidence 0.38 Published 2000 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 10840221 Disease Relevance 0 Pain Relevance 0.17
Taken together, the antinociceptive effect following TD feeding may result from a decrease in spinal SP and SST contents.
Negative_regulation (decrease) of SST in spinal associated with somatostatin, antinociceptive and substance p
8) Confidence 0.38 Published 2001 Journal Life Sci. Section Abstract Doc Link 11508348 Disease Relevance 0.14 Pain Relevance 1.00
I.t. administration of somatostatin (SOM) antiserum, cysteamine, a relatively selective depletor of SOM and cyclo-SOM, a SOM receptor antagonist, produced no inhibitory effect on the morphine-induced behaviour.
Negative_regulation (depletor) of cyclo-SOM associated with antagonist, somatostatin and morphine
9) Confidence 0.37 Published 1996 Journal Brain Res. Section Abstract Doc Link 8828571 Disease Relevance 0 Pain Relevance 1.61
These results suggest that the antinociceptive effect of mexiletine involves the inhibition of substance P-, somatostatin-, bradykinin- and PGF2 alpha-mediated nociceptive transmission in the spinal cord.
Negative_regulation (inhibition) of somatostatin in spinal cord associated with nociception, somatostatin, mexiletine, bradykinin, antinociceptive, spinal cord and substance p
10) Confidence 0.35 Published 1999 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 10445233 Disease Relevance 0.64 Pain Relevance 1.24
Somatostatin inhibition of gonadotropin-releasing hormone neurons in female and male mice.
Negative_regulation (inhibition) of Somatostatin in neurons associated with somatostatin
11) Confidence 0.31 Published 2010 Journal Endocrinology Section Title Doc Link 20410192 Disease Relevance 0 Pain Relevance 0.42
Pretreatment of AtT-20 cells with pertussis toxin abolished SRIF's inhibition of Bay K 8644-evoked Ca+(+) influx suggesting that G proteins mediate the inhibitory effects of SRIF on Ca+(+) influx.
Negative_regulation (inhibition) of SRIF in AtT-20 associated with bordatella infection and somatostatin
12) Confidence 0.30 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1696631 Disease Relevance 0.10 Pain Relevance 0.89
The neurochemical abnormalities include significant decreases in striatal Met-enkephalin and substance P (but not somatostatin), increases in concentrations of quinolinic acid and platelet-activating factor, and alterations in brain fyn kinase.
Negative_regulation (decreases) of somatostatin in brain associated with congenital anomalies, somatostatin, enkephalin and substance p
13) Confidence 0.26 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629308 Disease Relevance 1.17 Pain Relevance 0.32
In contrast to the brain opiates, however, the inhibitory effects of VIP, somatostatin and its analogues, and HPP were not reversed by the opiate antagonist naloxone.
Neg (not) Negative_regulation (reversed) of somatostatin in brain associated with antagonist, narcan, somatostatin and opiate
14) Confidence 0.23 Published 1978 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 733857 Disease Relevance 0 Pain Relevance 0.74
The desensitization of the kappa receptor was homologous, as the ability of somatostatin to mediate inhibition of adenylyl cyclase or potentiation of the K+ current was not altered by kappa receptor desensitization.
Neg (not) Negative_regulation (altered) of somatostatin associated with somatostatin
15) Confidence 0.22 Published 1998 Journal Neuroscience Section Abstract Doc Link 9639280 Disease Relevance 0 Pain Relevance 0.49
In addition, this hypothalamic effect of ghrelin is independent of somatostatin, the inhibitor of the GH axis, since it is also found in somatostatin knockout mice.
Neg (independent) Negative_regulation (independent) of somatostatin associated with targeted disruption and somatostatin
16) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2820089 Disease Relevance 0.18 Pain Relevance 0.28
Some mathematical models have incorporated an antagonistic effect of ghrelin on the hypothalamic effects of somatostatin [1], but this is not essential, since in the mouse, the stimulatory effect of ghrelin on GHRH neurons was observed in the absence of somatostatin.
Negative_regulation (absence) of somatostatin in neurons associated with somatostatin
17) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.10
Chronic depolarization causes differential effects on the peptidergic phenotypes increasing NPY and Enk but decreasing SS in both adrenal and sympathetic cultures.
Negative_regulation (decreasing) of SS in sympathetic associated with somatostatin and enkephalin
18) Confidence 0.16 Published 1995 Journal Brain Res. Section Abstract Doc Link 7613996 Disease Relevance 0.09 Pain Relevance 0.60
Although still controversial, the results of several studies have shown a possible influence of a local decrease in gastric somatostatin in the physiopathologic characteristics of peptic ulcer disease.
Spec (possible) Negative_regulation (decrease) of somatostatin associated with peptic ulcer disease, somatostatin and disease
19) Confidence 0.15 Published 1987 Journal Surg Gynecol Obstet Section Abstract Doc Link 3563843 Disease Relevance 0.85 Pain Relevance 0.43
In conclusion, these results suggest that decreased SS levels in antral gastric mucosa could be the alteration underlying the various physiopathologic mechanisms involved in the development of peptic ulcer disease.
Negative_regulation (decreased) of SS associated with peptic ulcer disease, somatostatin and disease
20) Confidence 0.13 Published 1987 Journal Surg Gynecol Obstet Section Abstract Doc Link 3563843 Disease Relevance 0.86 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox