INT339214

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1R) plasma membrane (IGF1R)
Anatomy Link Frequency
arms 2
IGF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 41 17.32 Low Low
headache 2 8.32 Low Low
Migraine 2 7.96 Low Low
nud 2 7.12 Low Low
Angina 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Prostatitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Solid Tumor 1 97.68 Very High Very High Very High
Cancer 108 89.92 High High
Disease 17 58.08 Quite High
Prostate Cancer 70 39.40 Quite Low
Malignant Neoplastic Disease 4 21.76 Low Low
Obesity 2 19.12 Low Low
INFLAMMATION 41 17.32 Low Low
Migraine Disorders 2 8.32 Low Low
Dyspepsia 2 7.12 Low Low
Breast Cancer 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We extended our IHC analysis to define a potential impact of IGF1R and EGFR protein expression in ERBB2-amplified patients.
Negative_regulation (impact) of Gene_expression (expression) of IGF1R
1) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.34 Pain Relevance 0
Similarly, no difference in the proportion displaying a 2-fold decrease in IGF-1R expression occurred for the lycopene and placebo arms (14 and 8%, respectively; p = 0.65).
Negative_regulation (decrease) of Gene_expression (expression) of IGF-1R in arms
2) Confidence 0.07 Published 2010 Journal Cancer Causes Control Section Body Doc Link PMC3002170 Disease Relevance 0 Pain Relevance 0
We also hypothesized (secondarily) that IGF-1R expression would be decreased by lycopene versus placebo.
Negative_regulation (decreased) of Gene_expression (expression) of IGF-1R
3) Confidence 0.07 Published 2010 Journal Cancer Causes Control Section Body Doc Link PMC3002170 Disease Relevance 0.06 Pain Relevance 0

General Comments

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