INT339249

Context Info Confidence 0.64 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.21 Pain Relevance 0.03

extracellular region (KISS1, GNRH1) signal transduction (GNRH1) extracellular space (GNRH1) cytoskeleton organization (KISS1) cell-cell signaling (GNRH1)

Anatomy Link Frequency neurons 1 KISS1 (Homo sapiens) GNRH1 (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 1 61.72 opiate 1 21.16 gABA 3 20.36 noradrenaline 1 18.52 Neurotransmitter 2 15.80 Neuropeptide 1 14.92 depression 2 5.00 alcohol 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Hypogonadotropic Hypogonadism 3 84.96 Precocious Puberty 4 66.88 Urological Neuroanatomy 1 57.84 Obesity 5 27.36 Cancer 3 5.00 Weight Gain 3 5.00 Osteoporosis 2 5.00 Depression 2 5.00 Anxiety Disorder 2 5.00 Insulin Resistance 1 5.00

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Anatomy

Negation

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Thus, GnRH neurons activation by kisspeptin is essential for the onset of puberty and there are data from mice that the activation of kisspeptin neurons are driven by circulating estradiol [14].

kisspeptin Positive_regulation (activation) of GnRH in neurons

1) Confidence 0.64 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.21 Pain Relevance 0.03

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