INT339251

Context Info Confidence 0.28 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0.12

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1) plasma membrane (KISS1R) cell-cell signaling (GNRH1) signal transducer activity (KISS1R)

Anatomy Link Frequency neurons 1 KISS1R (Homo sapiens) GNRH1 (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 1 91.64 opiate 1 51.08 gABA 3 50.28 noradrenaline 1 48.44 Neurotransmitter 2 45.72 Neuropeptide 1 44.84 depression 2 5.00 alcohol 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 1 87.76 Hypogonadotropic Hypogonadism 3 71.28 Precocious Puberty 4 9.04 Obesity 5 5.00 Cancer 3 5.00 Weight Gain 3 5.00 Osteoporosis 2 5.00 Depression 2 5.00 Anxiety Disorder 2 5.00 Insulin Resistance 1 5.00

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Kisspeptin and GPR54 are expressed in hypothalamic GnRH neurons, suggesting that both GnRHR and GPR54 may act as paracrine and/or autocrine regulators of GnRH neuronal function [11].

GPR54 Regulation (regulators) of GnRH in neurons

1) Confidence 0.28 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.23 Pain Relevance 0.12

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