INT339253

Context Info Confidence 0.25 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0.04

extracellular region (KISS1, GNRH1) signal transduction (GNRH1) extracellular space (GNRH1) cytoskeleton organization (KISS1) cell-cell signaling (GNRH1)

Anatomy Link Frequency median eminence 2 KISS1 (Homo sapiens) GNRH1 (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 1 72.56 opiate 1 32.00 gABA 3 31.20 noradrenaline 1 29.36 Neurotransmitter 2 26.64 Neuropeptide 1 25.76 depression 2 5.00 alcohol 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 1 68.68 Hypogonadotropic Hypogonadism 3 63.52 Precocious Puberty 4 45.44 Obesity 5 5.92 Cancer 3 5.00 Weight Gain 3 5.00 Osteoporosis 2 5.00 Depression 2 5.00 Anxiety Disorder 2 5.00 Insulin Resistance 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, Ramaswamy et al reported that, in primates, kisspeptin-beaded axons, surprisingly, made only infrequent contacts with GnRH neurons in the mediobasal hypothalamus, whereas, kisspeptin and GnRH axons were found in extensive and intimate association in the median eminence indicating that nonsynaptic communication at the level of the median eminence is a pathway contributing to the regulation of GnRH release by kisspeptin [12].

kisspeptin Regulation (regulation) of Localization (release) of GnRH in median eminence

1) Confidence 0.25 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.24 Pain Relevance 0.04

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