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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.63
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Casp1 (Mus musculus)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
IPN 6 100.00 Very High Very High Very High
Inflammation 102 98.56 Very High Very High Very High
cytokine 91 93.28 High High
Arthritis 2 64.88 Quite High
Dopamine 61 57.12 Quite High
Central nervous system 24 43.72 Quite Low
dopaminergic neurodegeneration 1 22.20 Low Low
chemokine 7 21.52 Low Low
Inflammatory mediators 4 5.48 Low Low
midbrain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 6 100.00 Very High Very High Very High
INFLAMMATION 122 98.56 Very High Very High Very High
Nociception 13 85.36 High High
Disease 109 78.16 Quite High
Arthritis 2 64.88 Quite High
Bacterial Infection 1 60.08 Quite High
Stress 4 55.56 Quite High
Pressure And Volume Under Development 6 47.76 Quite Low
Hyperalgesia 3 42.48 Quite Low
Neurodegenerative Disease 17 27.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that caspase-1 plays a crucial role in genesis of inflammatory pain by promoting IL-1?
caspase-1 Positive_regulation (promoting) of IL-1 associated with ipn
1) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 1.26 Pain Relevance 0.60
upregulates caspase-1, which in turn activates IL-1?)
caspase-1 Positive_regulation (activates) of IL-1
2) Confidence 0.03 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.37 Pain Relevance 0.20

General Comments

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