INT339333

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.32
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TAC4) plasma membrane (TACR1) cytoplasm (TACR1)
signal transducer activity (TACR1)
TACR1 (Homo sapiens)
TAC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 138 99.56 Very High Very High Very High
antagonist 60 98.00 Very High Very High Very High
agonist 21 92.80 High High
Inflammation 24 75.68 Quite High
Potency 6 15.52 Low Low
unmyelinated 3 10.64 Low Low
c fibre 3 9.60 Low Low
cytokine 42 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 6 99.84 Very High Very High Very High
INFLAMMATION 27 75.68 Quite High
Increased Venous Pressure Under Development 3 39.84 Quite Low
Nicotine Addiction 9 5.00 Very Low Very Low Very Low
Asthma 9 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 6 5.00 Very Low Very Low Very Low
Lung Cancer 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it can also be suggested that [Sar9,Met(O2)11] SP and SP on the one hand, and hHK-1 on the other hand, may bind to different sites of the NK1 receptor and interact in a different manner with receptor antagonists [5,56].
NK1 receptor Binding (bind) of hHK-1 associated with antagonist and substance p
1) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.06 Pain Relevance 0.57
Such a desensitization can be due to receptor internalization, which is a common phenomenon for NK1 receptor signaling [55] and has already been described with hHK-1 on astrocytoma cells [53].
NK1 receptor Binding (described) of hHK-1 associated with anaplastic astrocytoma
2) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.18 Pain Relevance 0.30
The biological action of tachykinins are mediated by at least three different transmembrane G-protein coupled receptors, namely NK1, NK2 and NK3 receptors which are stimulated preferentially, but not exclusively by SP, NKA and NKB, respectively [7-9]. r/mHK-1 has similar affinity to SP at the human NK1 receptor [4,6,10-12], while hHK-1 binds to the human NK1 receptor with a 14-fold lower affinity than SP [4].
NK1 receptor Binding (binds) of hHK-1 associated with substance p
3) Confidence 0.36 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.08 Pain Relevance 0.19

General Comments

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