INT339334

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TAC4) Golgi apparatus (B3GAT1) carbohydrate metabolic process (B3GAT1)
Anatomy Link Frequency
jugular veins 1
TAC4 (Homo sapiens)
B3GAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 92 99.90 Very High Very High Very High
agonist 14 97.32 Very High Very High Very High
antagonist 40 82.04 Quite High
cytokine 28 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
c fibre 2 5.00 Very Low Very Low Very Low
unmyelinated 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 4 96.64 Very High Very High Very High
Lung Cancer 4 21.16 Low Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Nicotine Addiction 6 5.00 Very Low Very Low Very Low
Asthma 6 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, HK-1 has been reported to induce a desensitization of NK1 receptors in human embryonic kidney cells [11], rabbit jugular veins [13], U251 MG astrocytoma cells [53] and scratching behavior in rats [54].
HK-1 Negative_regulation (desensitization) of NK1 in jugular veins associated with anaplastic astrocytoma
1) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.15 Pain Relevance 0.21
Since [Sar9,Met(O2)11] SP and hHK-1 are both able to induce a desensitization of NK1 receptors, we performed cross-desensitization experiments with the two compounds in order to assess if tissues desensitized with one peptide were still responsive to a subsequent addition of the other peptide.
hHK-1 Negative_regulation (desensitization) of NK1 associated with substance p
2) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0 Pain Relevance 0.31

General Comments

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