INT339435

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.37
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh5) plasma membrane (Cdh5)
Anatomy Link Frequency
vasculature 2
endothelial cells 1
Cdh5 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 148 93.88 High High
positron emission tomography 52 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 124 100.00 Very High Very High Very High
Cancer 456 99.22 Very High Very High Very High
Solid Tumor 12 71.44 Quite High
Disease 16 31.96 Quite Low
Infarction 4 27.08 Quite Low
Colon Cancer 12 5.00 Very Low Very Low Very Low
Toxicity 8 5.00 Very Low Very Low Very Low
Glioblastoma 4 5.00 Very Low Very Low Very Low
Prostate Cancer 4 5.00 Very Low Very Low Very Low
Cicatrix 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The construct rapidly accesses the tumor vasculature and then can specifically bind to the monomeric VE-cad that is expressed in the neovasculature but cannot bind to resting vasculature with tight cell–cell contacts at the adherens junctions.
VE-cad Binding (bind) of in vasculature associated with coronary artery disease and cancer
1) Confidence 0.31 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.92 Pain Relevance 0.08
The construct rapidly accesses the tumor vasculature and then can specifically bind to the monomeric VE-cad that is expressed in the neovasculature but cannot bind to resting vasculature with tight cell–cell contacts at the adherens junctions.
VE-cad Neg (cannot) Binding (bind) of in vasculature associated with coronary artery disease and cancer
2) Confidence 0.23 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.98 Pain Relevance 0.08
The number of VE-cad epitopes per tumor was measured and extrapolated to estimate a number of bound VE-cad epitopes per cell.
VE-cad Binding (bound) of associated with coronary artery disease and cancer
3) Confidence 0.23 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.70 Pain Relevance 0.15
Large interendothelial junctions in cancerous tissue may be as large as 500 nm, whereas in healthy tissue, these junctions are ~8 nm.7 Angiogenic endothelial cells express the monomeric vascular endothelial-cadherin (VE-cad) epitope on the cell surface that upon dimerizing with another monomeric copy of VE-cad on an adjoining cell surface leads to the formation of tight adherens junctions between the cells.8–12 The antibody E4G10 binds only to the monomeric VE-cad and not to the homodimeric form (the binding region is masked in the homodimers that form the tight cell–cell contacts), thus conferring the specificity for targeting angiogenic and poorly joined endothelial cells in vivo while not binding to normal endothelium or the LS174T tumor.
VE-cad Binding (binds) of in endothelial cells associated with coronary artery disease and cancer
4) Confidence 0.23 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.78 Pain Relevance 0

General Comments

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