INT33944

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Context Info
Confidence 0.24
First Reported 1986
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 2.86
Pain Relevance 8.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Helt) nucleus (Helt) DNA binding (Helt)
Anatomy Link Frequency
neurons 4
interneurons 2
tectum 1
spinal cord 1
inferior colliculus 1
Helt (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 115 100.00 Very High Very High Very High
GABAergic 84 100.00 Very High Very High Very High
Pyramidal cell 29 100.00 Very High Very High Very High
Locus ceruleus 22 100.00 Very High Very High Very High
Opioid 33 99.98 Very High Very High Very High
amygdala 25 99.76 Very High Very High Very High
Pain 16 99.50 Very High Very High Very High
gABA 75 99.40 Very High Very High Very High
Spinal cord 10 99.32 Very High Very High Very High
Morphine 89 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 34 99.72 Very High Very High Very High
Absence Epilepsy 3 99.26 Very High Very High Very High
Urological Neuroanatomy 4 96.96 Very High Very High Very High
Increased Venous Pressure Under Development 7 96.20 Very High Very High Very High
Targeted Disruption 116 92.96 High High
Convulsion 40 90.60 High High
Shock 3 82.40 Quite High
Pruritus 11 80.68 Quite High
Anxiety Disorder 19 80.20 Quite High
Sarcoma 1 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the TrkB inhibitor K-252a, or mice deficient for the common neurotrophin receptor p75(NTR), the regulation of GABAergic activity was shown specifically to be mediated by BDNF binding to the neurotrophin receptor TrkB.
Regulation (regulation) of GABAergic associated with gabaergic
1) Confidence 0.24 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19812317 Disease Relevance 0 Pain Relevance 0.50
However, it is unknown how proBDNF and mature BDNF affect the excitability of GABAergic interneurons and thereby regulate GABAergic inhibition.
Regulation (excitability) of GABAergic in interneurons associated with gabaergic
2) Confidence 0.18 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19812317 Disease Relevance 0 Pain Relevance 0.33
These findings suggest an opioid modulation of the GABAergic inhibitory inputs controlling the aversive behavior elicited by midbrain tectum stimulation.
Regulation (modulation) of GABAergic in tectum associated with gabaergic, midbrain and opioid
3) Confidence 0.16 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11750915 Disease Relevance 0.39 Pain Relevance 0.88
The modulation of GABAergic neuron activity by zinc may be important for the functions of the amygdala.
Regulation (modulation) of GABAergic in amygdala associated with gabaergic and amygdala
4) Confidence 0.16 Published 2002 Journal Brain Res. Section Abstract Doc Link 11988235 Disease Relevance 0 Pain Relevance 0.69
It seems that Pasipay could be useful for treatment absence seizure and these effects may be related to effect of it on GABAergic and opioid systems.
Regulation (effect) of GABAergic associated with gabaergic, absence epilepsy and opioid
5) Confidence 0.04 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1973074 Disease Relevance 0.73 Pain Relevance 0.35
Thus cerebellar alpha-adrenoceptors play roles in a presynaptic dual modulation of GABAergic inputs from interneurons to PCs, thereby providing a likely mechanism for the fine-tuning of information flow in the cerebellar cortex.
Regulation (modulation) of GABAergic in cerebellar cortex associated with gabaergic
6) Confidence 0.03 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16251261 Disease Relevance 0 Pain Relevance 0.63
To further examine the role of GABAergic interneurons in the effect of morphine, the GABAB receptor agonist; SKF 97541, and GABAB receptor antagonist; CGP 55845, were administered after morphine injections in WT and KO mice.
Spec (examine) Regulation (role) of GABAergic in interneurons associated with targeted disruption, antagonist, gabaergic, agonist and morphine
7) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.42 Pain Relevance 1.67
We found that GRP increased the frequency of sIPSCs recorded while had no significant effect on sEPSCs in ACC pyramidal neurons.
Neg (no) Regulation (effect) of neurons in pyramidal neurons associated with pyramidal cell and anterior cingulate cortex
8) Confidence 0.02 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2945970 Disease Relevance 0.16 Pain Relevance 0.43
The present work evaluates the effect of GABAergic activity, via GABA(A) receptors, on LHRH neuropeptide gene expression in LHRH neurons maintained in olfactory explants generated from E11.5 mouse embryos.
Regulation (effect) of GABAergic in olfactory associated with gaba, gabaergic and neuropeptide
9) Confidence 0.02 Published 1998 Journal Endocrinology Section Abstract Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.44
Regulation of early spontaneous network activity and GABAergic neurons development by thyroid hormone.
Regulation (Regulation) of GABAergic in thyroid associated with gabaergic
10) Confidence 0.01 Published 2010 Journal Neuroscience Section Title Doc Link 20338226 Disease Relevance 0 Pain Relevance 0.33
Nociceptive responses to altered GABAergic activity at the spinal cord.
Regulation (altered) of GABAergic in spinal cord associated with pain, gabaergic and spinal cord
11) Confidence 0.01 Published 1986 Journal Life Sci. Section Title Doc Link 3022091 Disease Relevance 0.54 Pain Relevance 0.83
Postsynaptic currents (PSCs) were recorded using the patch-clamp technique in neurons of the rat inferior colliculus (IC) to investigate the muscarinic modulation of the GABAergic transmission.
Spec (investigate) Regulation (modulation) of GABAergic in inferior colliculus associated with gabaergic
12) Confidence 0.01 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12907311 Disease Relevance 0.07 Pain Relevance 0.28
Although presumed GABAergic sleep-promoting neurons in the VLPO have been reported to be unaffected by histamine (Gallopin et al., 2000, but see Liu et al., 2010), some of these cotransmitters might have inhibitory or excitatory actions on these sleep-promoting neurons.


Neg (unaffected) Regulation (unaffected) of neurons in neurons associated with gabaergic
13) Confidence 0.01 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0.05 Pain Relevance 0.38
Early electron microscopic observations revealed that only 3 of 25 serially cut HDC-immunoreactive axonal varicosities formed synaptic contacts (Hayashi et al., 1984), leading to the postulate that the majority of HA axons release histamine non-synaptically and that this non-synaptically released histamine affects neurons in the vicinity in the same way as neurohormones or neuromodulators (Hayashi et al., 1984; Wada et al., 1991), as seen with other biogenic amines (Beaudet and Descarries, 1978).
Regulation (affects) of neurons in neurons associated with increased venous pressure under development
14) Confidence 0.01 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0.22 Pain Relevance 0.37
We have also demonstrated that HCRT2-SAP kills neurons in the tuberomammillary nucleus that contain the HCRT-2 receptor [29], whereas the neurons in the locus coeruleus, which contain the HCRT-1 receptor are relatively resistant [12].
Regulation (resistant) of neurons in neurons associated with locus ceruleus
15) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.19 Pain Relevance 0.05
GABAergic pathways to these neurons have recently been described, yet modulation of this GABAergic input and its impact upon cardiac vagal neurons is unknown.
Regulation (modulation) of GABAergic in neurons associated with gabaergic
16) Confidence 0.00 Published 2002 Journal Neuroscience Section Abstract Doc Link 12182901 Disease Relevance 0.08 Pain Relevance 0.33

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